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EC number: 403-920-4 | CAS number: 107551-67-7 G 19-675 ZP
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Mar. 3, 1988 to May 5, 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, according to accepted guideline, with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
- EC Number:
- 403-920-4
- EC Name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propionic acid
- Cas Number:
- 107551-67-7
- Molecular formula:
- C13H18O3
- IUPAC Name:
- 3-(3-tert-butyl-4-hydroxyphenyl)propanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAI f (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Ltd. Animal Production 4332 Stein / Switzerland.
- Age at study initiation: 7 to 8 weeks.
- Weight at study initiation: 220 to 248 g.
- Housing: The rats, segregated by sex, were individually housed in Macrolon cages type 3, with standardized soft wood bedding (Societe Parisienne des Sciures, Pantin).
- Diet (e.g. ad libitum): ad libitum.
- Water (e.g. ad libitum): ad libitum.
- Acclimation period: At least 5 days before application.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2°C.
- Humidity (%): 55 ± 10%.
- Air changes (per hr): Approximately 15 air changes per h.
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- peanut oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Back of the rat.
- % coverage: At least 10% of the body surface.
- Type of wrap if used: was covered with a gauze-lined semiocclusive dressing fastened around the trunk with an adhesive elastic bandage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lukewarm water.
- Time after start of exposure: 24 hours.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4 mL/kg body weight.
- Concentration (if solution): 2000 mg/kg body weight. - Duration of exposure:
- 24 hours.
- Doses:
- 2000 mg/kg body weight.
- No. of animals per sex per dose:
- 5 per sex.
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing:
Mortality: Daily; a.m. and p.m. on working days, a.m. on weekend days.
Signs and symptoms: Daily.
Body weight: At start and on Days 7 and 14.
Necropsies: The animals were submitted to a gross necropsy at the end of the observation period.
- Necropsy of survivors performed: Yes. - Statistics:
- From the body weights, the group means and their standard deviations were calculated.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality.
- Clinical signs:
- other: Ruffled fur, dyspnea, and abnormal body positions were seen, being common symptoms in acute tests. Additionally, reduced spontaneous activity was observed during the application day and Day 1 after application. The animals recovered within 10 days. Ref
- Gross pathology:
- No deviations from normal morphology were found.
- Other findings:
- Not available.
Any other information on results incl. tables
Table 1 Signs and symptons
observations |
Exposure day: hours |
Days of post-exposure period |
||||||||||||||||
|
1 |
2 |
3 |
5 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
>13 |
2000 mg/kg males |
||||||||||||||||||
ruffled fur |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
|
|
|
|
|
dyspoea |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
|
|
|
|
|
|
|
|
hunched post. |
|
|
|
|
X |
X |
X |
X |
|
|
|
|
|
|
|
|
|
|
ventr.recumb. |
X |
X |
X |
X |
X |
|
|
|
|
|
|
|
|
|
|
|
|
|
red.spot.act. |
X |
X |
X |
X |
X |
|
|
|
|
|
|
|
|
|
|
|
|
|
2000 mg/kg females |
||||||||||||||||||
ruffled fur |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
|
|
|
|
|
dyspoea |
X |
X |
X |
X |
X |
X |
X |
X |
X |
X |
|
|
|
|
|
|
|
|
hunched post. |
|
|
|
|
X |
X |
X |
X |
|
|
|
|
|
|
|
|
|
|
ventr.recumb. |
X |
X |
X |
X |
X |
|
|
|
|
|
|
|
|
|
|
|
|
|
red.spot.act. |
X |
X |
X |
X |
X |
|
|
|
|
|
|
|
|
|
|
|
|
|
Table 2 Mean body weight and standard deviation
|
Males |
Females |
||||
Dose (mg/kg) |
Day 1 |
Day 7 |
Day 14 |
Day 1 |
Day 7 |
Day 14 |
2000 |
240/ 9.4 |
278/16.3 |
310/23.2 |
233/ 7.7 |
246/10.0 |
256/ 7.8 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Single dermal administration of the test substance (OECD guideline 402) to rats did neither induce mortalities nor adverse effects. LD50 is considered to be > 2000 mg/kg bw.
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