Registration Dossier
Registration Dossier
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EC number: 205-642-7 | CAS number: 144-83-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: with scientific toxicity testing methodology
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Salicylazosulfapyridine (SASP)
- IUPAC Name:
- Salicylazosulfapyridine (SASP)
- Test material form:
- not specified
- Details on test material:
- No data
Constituent 1
Method
- Target gene:
- salmonella typhimurim histidine(his) reversion system; E. coli
Species / strain
- Species / strain / cell type:
- other: TA95, TA98, TA100, TA1535, WP2p, WP2 uvrA-p
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- s9 Mix
- Test concentrations with justification for top dose:
- 0.4 to 6250 μg/plate
- Vehicle / solvent:
- corn oil
- Details on test system and experimental conditions:
- No data
- Evaluation criteria:
- No data
- Statistics:
- No data
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The test article showed no mutagenic effect for Salmonella typhimurium and E. coli at all test concentrations. - Executive summary:
The study was performed with the Salmonella typhimurium(TA 95,TA 100, TA 1535, WP2p and WP2 uvrA-p ) at dose levels from 0.4 to 6250 μg/plate both in the presence and absence of metabolic activation to check the potential of mutagenicity. No mutagenic effect was found. Thus, we can conclude the substance dose not induce mutagenicity.
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