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EC number: 203-897-9 | CAS number: 111-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Contribution à l'étude toxicologique de l'alcool heptylique
- Author:
- R. Truhaut
- Year:
- 1 974
- Bibliographic source:
- Archives des maladies professionelles de médecine du travail, 35, 4-5, Avril-Mai,(p 501-509).
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Heptan-1-ol
- EC Number:
- 203-897-9
- EC Name:
- Heptan-1-ol
- Cas Number:
- 111-70-6
- Molecular formula:
- C7H16O
- IUPAC Name:
- heptan-1-ol
- Details on test material:
- CAS No. 111-70-6
name= n-heptanol-1
Purity>97%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Strain= wistar
Weight =males (approx. 250g) and females (approx. 200g)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- 2500, 3500, 4100, 6150, 8200, 10250, 12300 mg/kg
- No. of animals per sex per dose:
- 10 animals/sex/group
- Control animals:
- no
- Details on study design:
- After administration of the test item, the animals were submitted to a 2-weeks observation period and the mortality rate and clinical signs were recorded. Post-mortem examination was performed.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 6 200 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 500 mg/kg bw
- Mortality:
- Generally death appeared during the first 48 hours after dosing. No animals were found dead after the sixth days of dosing.
2500 mg/kg: no death.
3500 mg/kg : 1/10 males dead and 1/10 females dead,
4100 mg/kg: 2/10 males dead and 3/10 females dead,
6150 mg/kg : 6/10 females dead
8200 mg/kg: 3/10 females dead and 7/10 females dead,
10250 mg/kg: 8/10 males dead
12300 mg/kg: 9/10 males dead and 10/10 females dead. - Clinical signs:
- other: Lung edema were observed in death animals at post-mortem examination.
- Gross pathology:
- Symptoms of acute lung edema were observed in the dead animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Directive EC No. 1272/2008
- Conclusions:
- The oral LD50 of Heptanol was 6200 +/- 700 mg/kg for males rats and 5500 +/- 500 mg/kg for the females.
- Executive summary:
The acute oral toxicity study was evaluated in rats for n-heptanol-1. The acute toxicity was considered low for each of the males and the females. During the necropsy examinaqtion, signs of irritation were recorded for the lung parenchyma for the male rat. Indeed, acute edema of the lung was recorded for the animals found dead few hours after test item administration, this was substantiated by inflamation of the lung alveolar and hemosiderin deposits.In the males rats, congestion and inflammation of the lung were associated with lesions in the lungs but the incidence was not dose-related. In the females rats, kidney dilatation was observed at the highest dose-levels. No other effects were observed on the sampled organs.
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