Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-659-4 | CAS number: 7681-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Study was conducted to determine the effect of test chemical on Dreissena polymorpha.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other aquatic mollusc: Dreissena polymorpha
- Details on test organisms:
- LIFE STAGE : Adult(s)COMMENT : 1.5-2.0 cm
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 24 h
- Hardness:
- No data
- Test temperature:
- 20 deg C
- pH:
- 7
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 226 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- no
- Conclusions:
- The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L.
- Executive summary:
Study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.
Reference
Description of key information
Study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 226 mg/L
Additional information
Data available for test chemicals including structurally and functionally similar read across chemical, study has been reviewed to determine the short term toxicity of the test chemical on the growth and mobility of daphnia magna. The studies are as mentioned below:
The first study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.
First study was supported by the second study from experimental report. The study was designed to assess the toxic effects of the test compound on the test Daphnids. Beaker containing 20ml of media with 10 Daphinds. A static procedure was used for the study and it was conducted in compliance with the OECD guideline 202. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively. The test concentrations selected for the study was 100 mg/L. The test vessels used were all glass beaker having the water capacity of 25ml, in each vessel 10 daphnia were incorporated. Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment. Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L. This value indicates that the substance is likely to be nonhazardous to aquatic invertebrate and cannot be classified as per the CLP criteria.
Similar study was conducted to investigate the effect of test chemical on the growth of daphnia magna. Study conducted according to the ISO 6341 15 "Water quality – Determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea)". Test chemical exposed with the daphnia magna for 48 hrs. After the exposure of test chemical with the daphnia magna for 48 hrs, EC0 no effect were observed on the mobility at the concentration 940 mg/l. Thus on the basis of above result it can be concluded that the chemical was nontoxic and not classified as per the CLP classification criteria.
Thus based on the above results, chemical consider to be nontoxic and thus not classified as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.