Registration Dossier
Registration Dossier
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EC number: 202-550-9 | CAS number: 96-99-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 4-chloro-3-nitrobenzoic acid
- EC Number:
- 202-550-9
- EC Name:
- 4-chloro-3-nitrobenzoic acid
- Cas Number:
- 96-99-1
- Molecular formula:
- C7H4ClNO4
- IUPAC Name:
- 4-chloro-3-nitrobenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- dimethylformamide
- Concentration:
- 25% W/W
- No. of animals per dose:
- 4
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 11.18
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 73921.80
Any other information on results incl. tables
| Concentration (% w/w) in dimethyl formamide | dpm | dpm/Node | Stimulation Index | Result |
| Vehicle | 6614.86 | 826.86 | Not applicable | Not applicable |
| 5 | 26415.80 | 3301.98 | 3.99 | Positive |
| 10 | 39047.01 | 4880.88 | 5.90 | Positive |
| 25 | 73921.80 | 9240.23 | 11.18 | Positive |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The test material was considered to be a sensitiser under the conditions of the test.
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