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Diss Factsheets
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EC number: 252-156-6 | CAS number: 34690-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- This is an accepted calculation method supported by a limited amount of additional validation.
- Justification for type of information:
- See attached QMRF and QPRF
- Principles of method if other than guideline:
- Method: other (calculated): Estimation by KOWWIN program, USEPA/Syracuse Research, v1.40 (see attached QMRF and QPRF).
- GLP compliance:
- no
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- -4
- Temp.:
- 20 °C
- pH:
- < 1
- Remarks on result:
- other: The log Kow of the dissociated form would also be expected to be extremely low.
- Conclusions:
- A predicted log Kow limit value of -4 was determined for the substance using a relevant estimation method. The result is considered reliable.
Reference
Description of key information
log Kow (BHMT-H): -4 (QSAR)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -4
- at the temperature of:
- 20 °C
Additional information
A predicted log Kow of -4 at 20°C was determined for the substance uisng a validated QSAR estimation method. The result is considered reliable and selected as key study. A measured limit log Kow value of <0 was determined for the substance using OECD 117 and in compliance with GLP. However, no information on pH and temperature was reported. The predicted log Kow represent that of the unionised species.
BHMT-H and its sodium and potassium salts are freely soluble in water. The BHMT anion can be considered fully dissociated from its sodium or potassium cations when in dilute solution. Under any given conditions, the degree of ionisation of the BHMT species is determined by the pH of the solution. At a specific pH, the degree of ionisation is the same regardless of whether the starting material was BHMT-H or a salt of BHMT.
The log Kow for an ionising substance will vary with pH as the ionised species will have a greater hydrophilicity and lower log Kow than the neutral species.
For further details of the speciation of BHMT-H see PFA 2020.
In a secondary source, a limit log Kow value of <0 was reported for the substance, full details are not available and the reliability is unassignable.
HMDTMP-H is a named impurity in the registered substance. Log Kow values of -4.7 and -4.1 at 100 ppm and 1000 ppm respectively were reported for HMDTMP-H in a reliable study conducted according to generally accepted scientific principles comparable to an appropriate test guideline. The method has been adequately described in the report.
Reference:
PFA 2020: BHMT speciation at pH relevant to Ecotoxicology and Toxicology, Reference: PFA.224.603.001, June 2020.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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