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EC number: 241-972-8 | CAS number: 18063-03-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sep - Oct 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, near guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-difluorobenzamide
- EC Number:
- 241-972-8
- EC Name:
- 2,6-difluorobenzamide
- Cas Number:
- 18063-03-1
- Molecular formula:
- C7H5F2NO
- IUPAC Name:
- 2,6-difluorobenzamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Batch number: 722.35
ST number: ST86/206
Characterisation: no purity data available- commercial sample
Appearance: white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K., Ltd.
- Age at study initiation: 9 to 11 weeks
- Fasting period before study: animals were fasted overnight (18 hours)
- Weight at study initiation: 190 g (males) and 138 g (females)
- Housing: single sex groups of 2-3 in cages with stainless-steel wire-mesh floors and tops; each cage measured 38 x 25 x 18 cm
- Diet: PRD (Labsure animal Foods, Dorset, UK), ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- DMSO
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50% in DMSO (m/v) - Doses:
- 780-3200 mg/kg bw
- No. of animals per sex per dose:
- 780 mg/kg bw: 4
1250 mg/kg bw: 8
1500 mg/kg bw: 4
2000 mg/kg bw: 8
2500 mg/kg bw: 4
3200 mg/kg bw: 4 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days;
- Frequency of observations and weighing: Observations were recorded three times a day for the first three days and daily thereafter. The initial (i.e. day 1), day 7 and day 14 body weights were recorded;
- Necropsy of survivors performed: no;
- Other examinations performed: clinical signs and body weight. - Statistics:
- prohibit analyis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 576 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: given the disparity in response between males and females, a combined LD50 values is not quoted
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 075 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: given the disparity in response between males and females, a combined LD50 values is not quoted
- Mortality:
- 780 mg/kg bw: males: 0/4; females: 0/4
1250 mg/kg bw: males: 0/8; females: 6/8
1500 mg/kg bw: males: 0/4; females: 4/4
2000 mg/kg bw: males: 1/8; females: 8/8
2500 mg/kg bw: males: 1/4; females: 4/4
3200 mg/kg bw: males: 4/4; females: 4/4 - Clinical signs:
- other: The incidence and duration of clinical signs were dose-related. The commonest clinical signs seen indicated a neurological action since they included gait and posture abnormalities and prostration, the sequela to the latter being coma in some cases.
- Gross pathology:
- Not investigated.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of the test item in female rats was calculated to be 1075 mg/kg bw and in male rats 2576 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test substance was investigated in Fischer 344 rats. The test substance was administered orally by gavage at 780, 1250, 1500, 2000, 2500 and 3200 mg/kg bw. Animals were subjected to observations and determination of the body weight. Mortality occurred at concentrations from 1250 up to 3200 mg/kg bw in females and from 2000 up to 3200 mg/kg bw in males. The incidence and duration of clinical signs were dose-related. The commonest clinical signs seen indicated a neurological action since they included gait and posture abnormalities and prostration, the sequela to the latter being coma in some cases. All surviving animals had gained weight relative to their day 1 bodyweights by the end of the 14 day observation period.
The acute oral median lethal dose (LD50) of the test item in female rats was calculated to be 1075 mg/kg bw and in male rats 2576 mg/kg bw.
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