Registration Dossier
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EC number: 202-608-3 | CAS number: 97-78-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 (72 h): 79 mg/L and; NOEC (72 h): 9.2 mg/L for Desmodesmus subspicatus based on growth rate (OECD 201) (read-across)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 79 mg/L
- EC10 or NOEC for freshwater algae:
- 9.2 mg/L
Additional information
No studies investigating the toxicity of N-lauroylsarcosine (CAS 97-78-9) to aquatic algae are available. Therefore, data from the corresponding salt, Sodium N-lauroylsarcosinate (CAS 137-16-6), are used as read-across. This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in IUCLID Section 13. Since dissociation of the sodium salt under environmental conditions yields the same ionic species as dissociation of the acidic form of the substance, this read across can be considered as justified.
The toxicity of the read-across substance Sodium N-lauroysarcosinate (CAS 137-16-6) to aquatic algae was investigated in an algal growth inhibition test with Desmodesmus subspicatus according to OECD 201 and GLP (Vryenhoef and Mullee, 2010). The test included a valid reference control and analytics to verify the nominal test concentrations. An ErC50 (72 h) of 79 mg/L based on growth and an EyC50 (72 h) of 39 mg/L based on yield are reported. Both effect concentrations reflect the geometric mean of the measured concentrations. The NOEC was found to be 9.2 mg/L based on geometric mean measured concentrations.
Based on the available result from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5.) which is characterized by a comparable structure, it can be concluded that N-lauroylsarcosine (CAS 97-78-9) will show a similar toxicity to aquatic algae.
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