Registration Dossier
Registration Dossier
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EC number: 939-383-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Data on bioaccumulation for the test item are not available. However, the substance is regarded as not bioaccumulative due to its high molecular weight (1211,36 (C12) - 1239,41(C14)) and the average maximum diameter (Dmaxaver) of above 1.7 nm. CATALOGIC v5.11.5 was used to calculate the Dmaxaver. Due to the high molecular weight CATALOGIC was not able to calculate the Dmaxaver for the complete complex. Therefore, Dmaxaver was only calculated for the organic part of the complex as worst case (SMILES: CCC(C)(C)c1cc(c(c(c1)N(=O)=O)O)/N=N/c2c(nn(c2O)c3cccc(c3)S(=O)(=O)N)C). It resulted in a Dmaxaver of 1.95.
According to the guidance on information requirements and chemical safety assessment Chapter R.11 - PBT Assessment - a molecular weight higher than 1100 g/mol is an indicator that the aquatic BCF of the respective substance is lower than 2000 L/kg. If the substance has a molecular weight higher than 700 g/mol this is an indicator that the BCF is below 5000 L/kg. Furthermore, another parameter that directly reflects the molecular size of a substance is the average maximum diameter (Dmaxaver). Very bulky molecules will less easily pass the cell membranes. This results in a reduced BCF of the substance. From a diverse set of chemicals it appeared that for compounds with a Dmaxaverlarger than 1.7 nm the BCF value was less than 5000 L/kg. It can be assumed combining the maximum diameter of above 1.7 nm and the high molecular size of the test item that the test item will not easily pass the cell membranes, the uptake is reduced and bioaccumulation will not occur.
Additionally, a logPow of 9.6 was calculated (CIBA-GEIGY Ltd 1992). According to the guidance on information requirements and chemical safety assessment Chapter R.11 - PBT Assessment - the aquatic BCF of a substance is probably lower than 2000 L/kg if the calculated loKow is higher than 10.
In overall conclusion, a significant accumulation in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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