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EC number: 241-475-6 | CAS number: 17462-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- sec-butyl chloroformate
- EC Number:
- 241-475-6
- EC Name:
- sec-butyl chloroformate
- Cas Number:
- 17462-58-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butan-2-yl carbonochloridate
- Reference substance name:
- sec. Butylchloroformate
- IUPAC Name:
- sec. Butylchloroformate
- Reference substance name:
- 83/282
- IUPAC Name:
- 83/282
- Details on test material:
- - Name of test material (as cited in study report): sec.-Butylchlorformiat (butyl carbonochloridic acid ester)- Physical state: clear liquid- Analytical purity: ca. 99%- Impurities (identity and concentrations): traces of phosgen, di-sec.-butylcarbonate, 2-chlorbutane, HCl- Expiration date of the lot/batch: end of march 1984- Stability under test conditions: max. 24 h- Storage condition of test material: < 5°C
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Dr. Thomae, Biberach, D- Mean weight per group at study initiation: males 177 - 187 g, females 178 - 187 g - Fasting period before study: 16 h- Diet (e.g. ad libitum): Kliba Labordiaet, Klingentalmuehle AG, Kaiseraugst, CH- Water (e.g. ad libitum): tap water- Acclimation period: at least 7 dENVIRONMENTAL CONDITIONS- Temperature (°C): 20 - 24- Humidity (%): 30 - 70- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
- Doses:
- 562, 1000 and 1780 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days- Frequency of observations and weighing: Weighing was performed at the beginning and on d4, d7 and d14. Observations were performed several times on the day of application and at least once per workday- Necropsy of survivors performed: yes
- Statistics:
- not performed
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 - 1 780 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 527 mg/kg bw
- Remarks on result:
- other: value extrapolated
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 527 mg/kg bw
- Remarks on result:
- other: value extrapolated
- Mortality:
- No mortality observed in the 562 and 1000 mg/kg dose groups. In the 1780 mg/kg dose group, 4/5 males and 4/5 females, respectively, died at least within 2 d
- Clinical signs:
- 562 mg/kg: diarrhea; reversible within 2 h1000 mg/kg: staggering, diarrhea and imbalance; reversible within at least 8 d1780 mg/kg: dyspnea, apathy, staggering, piloerection, diarrhea and poor general state; reversible within at least 5 d
- Body weight:
- The mean body weight gain of the 1000 and 1780 mg/kg dose groups in males (36-30 g) was slightly reduced if compared with the 562 mg/kg dose group in the first week (53 g), while the mean body weight gain of the females over the whole observation period and of the males in the second week was comparable between all dose groups.
- Gross pathology:
- Animals that died: General congestive hyperemia; stomach: haemorrhagic gastritis in glandular stomach.Sacrificed animals: Gastric wall of the forestomach thickened.
Applicant's summary and conclusion
- Executive summary:
The study is conducted similar to OECD 401 and is reliable without restrictions. Male and female Wistar rats were treated with 562, 1000 or 1780 mg/kg test substance by gavage. No mortality was observed in doses up to 1000 mg/kg. The acute LD50 of sec.-Butylchloroformate in rats lies between 1000 - 1780 mg/kg after oral application. Haemorrhagic gastritis in glandular stomach was found in animals found dead and thickened gastric wall of the forestomach in sacrificed animals at necropsy.
Conclusion
According to the results of the present study the test substance, sec-Butylchloroformate has to be regarded as harmful after single oral application (R 22 according to EU classification criteria; acute oral Cat. 4 according to GHS criteria).
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