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EC number: 282-486-6 | CAS number: 84238-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source (documentation insufficient for assessment), but used in the Cosmetic Ingredient Review (CIR) assessment report.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Skin sensitization potential of coconut oil was determined in guinea pigs using Magnusson-Kligman Maximization Procedure.
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- Cas Number:
- 67701-28-4
- IUPAC Name:
- Glycerides, C8-18 and C18-unsatd.
- Details on test material:
- - Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: propylene glycol
- Concentration / amount:
- Induction: 5%
Booster: 100%
Challenge: 50 and 100%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: propylene glycol
- Concentration / amount:
- Induction: 5%
Booster: 100%
Challenge: 50 and 100%
- No. of animals per dose:
- 10 animals both in test and control groups
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
Test animals: received two injections of each of the following in separate locations on the back:
1) 50% aqueous Freund’s complete adjuvant
2) 5% coconut oil in propylene glycol
3) 5% coconut oil in 50% Freund’s complete adjuvant
Control animals: received the same treatment regimen of vehicles only.
B. BOOSTER EXPOSURE
Test animals: 1 wk after induction, 5% sodium lauryl sulfate in petrolatum was applied to each induction site. 24 h later, a topical booster of 100% coconut oil was applied to the same sites.
Control animals: received 5% sodium lauryl sulfate in petrolatum and, 24 h later, full strength petrolatum as a booster. All control and test animals were wrapped occlusively for 48 h.
C. CHALLENGE EXPOSURE
2 wks after the topical booster, the animals were challenged with topical applications of 50% and 100% coconut oil via 24 h occlusive patch. The challenge sites were graded 48 and 72 h after the beginning of the challenge. - Challenge controls:
- Same treatment as used for test group but using only the vehicle
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Concentration:
- Not applicable
- No. of animals per dose:
- Not applicable
- Details on study design:
- Not applicable
- Statistics:
- No data
Results and discussion
- Positive control results:
- Not applicable
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Not applicable
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Not applicable
Any other information on results incl. tables
Coconut oil was non-irritating and failed to produce an allergic response (no further details reported).
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Under the test conditions, the test substance was found to be non-sensitizing to guinea pig skin.
- Executive summary:
‘Glycerides, C8-18 and C18-unsatd.’ (as coconut oil) was evaluated for skin sensitization potential in guinea pig using the Magnusson-Kligman Maximization Procedure.
10 test animals and 10 controls were used in the induction, booster, and challenge phases. Induction was done by intradermal injection of 5% the test substance with Freund’s complete adjuvant. 1 wk after induction, 5% sodium lauryl sulfate in petrolatum was applied to each induction site. 24 h later, a topical booster of 100% test substance was applied to the same sites. 2 wks after the topical booster, the animals were challenged with topical applications of 50% and 100% test substance. Sites were graded after 48 and 72 h of challenge application.
Coconut oil was non-irritating and failed to produce an allergic response.
Under test conditions, the test substance was found to be non-sensitizing to guinea pig skin.
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