Registration Dossier
Registration Dossier
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EC number: 206-056-4 | CAS number: 298-07-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficient documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Bis(2-ethylhexyl) hydrogen phosphate was administered undiluted at a dose level of 2000 mg/kg bw to 3 male and 3 female New Zealand rabbits. Bis(2-ethylhexyl) hydrogen phosphate was applied under gauze (8 ply) and occlusive rubber for 24 hours. The animals were observed for mortality, body weight and clinical signs.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bis(2-ethylhexyl) hydrogen phosphate
- EC Number:
- 206-056-4
- EC Name:
- Bis(2-ethylhexyl) hydrogen phosphate
- Cas Number:
- 298-07-7
- Molecular formula:
- C16H35O4P
- IUPAC Name:
- bis(2-ethylhexyl) hydrogen phosphate
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2 male and 1 female rat with abradded skin
1 male and 2 female rats with intact skin - Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
There were no deaths after administration of bis(2-ethylhexyl) hydrogen phosphate. There was no significant change in body weights after 14 days. No toxic signs were observed. Bis(2-ethylhexyl) hydrogen phosphate elicited signs of severe irritation in all animals. Eschar and severe edema were observed and persisted through the study.
Applicant's summary and conclusion
- Executive summary:
Bis(2-ethylhexyl) hydrogen phosphate was administered undiluted at a dose level of 2000 mg/kg bw to 3 male and 3 female New Zealand rabbits. Bis(2-ethylhexyl) hydrogen phosphate was applied under gauze (8 ply) and occlusive rubber for 24 hours. The animals were observed for mortality, body weight and clinical signs.
There were no deaths after administration of the test compound. There was no significant change in body weights after 14 days. No toxic signs were observed. Bis(2-ethylhexyl) hydrogen phosphate elicited signs of severe irritation in all animals. Eschar and severe edema were observed and persisted through the study. A dermal LD50 > 2000 mg/kg bw was determined.
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