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Diss Factsheets
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EC number: 203-537-0 | CAS number: 107-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert judgement is combined with the prediction of metabolism provided by the OECD QSAR Application Toolbox.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- No guideline exists for this type of appraisal.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-mercaptopropionic acid
- EC Number:
- 203-537-0
- EC Name:
- 3-mercaptopropionic acid
- Cas Number:
- 107-96-0
- Molecular formula:
- C3H6O2S
- IUPAC Name:
- 3-sulfanylpropanoic acid
- Details on test material:
- not applicable
Constituent 1
Test animals
- Species:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: oral and dermal route are considered
- Details on exposure:
- not applicable
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- MPA is predicted to be moderately bioavailable (50%) via the oral route and readily absorbed via skin.
- Details on distribution in tissues:
- MPA and its metabolites are very polar and are predicted to have no accumulation potential. They are expected to be enter the urine shortly after systemic absorption.
- Details on excretion:
- MPA as well as the oxidised metabolites are very polar and will be excreted rapidly via urine. Faecal excretion is not expected.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- MPA is expected to undergo stepwise oxidation of the thiol group yielding 3-sulfinopropanoic acid and 3-sulfopropanoic acid. Both substances are very polar and thus subject to renal elimination.
In addition, disulphide bridge formation with cysteine or with another MPA molecule may occur.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: no bioaccumulation potential based on study results
MPA is predicted to be moderately bioavailable (50%) via the oral route and readily absorbed via skin.
MPA is expected to undergo stepwise oxidation of the thiol group and also disulphide bridge formation with cysteine or with another MPA molecule.
MPA and its metabolites are very polar and thus subject to renal elimination. Tissue accumulation can be excluded. - Executive summary:
- The toxicokinetic behaviour of MPA
[3-mercaptopropionic acid] was assessed. The OECD QSAR Application Toolbox
was used to make a qualitative prediction of metabolites formed in liver,
skin and gastrointestinal tract.
The Danish QSAR Database was used to predict dermal and oral bioavailability of MPA.
The fate of these metabolites is predicted on the basis of their chemical structure based on expert judgement.
MPA is predicted to be moderately bioavailable (50%) via the oral route and readily absorbed via skin.
MPA is expected to undergo stepwise oxidation of the thiol group yielding 3-sulfinopropanoic acid and 3-sulfopropanoic acid. Both substances are very polar and thus subject to renal elimination.
In addition, disulphide bridge formation with cysteine or with another MPA molecule may occur.
Tissue accumulation can be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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