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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1995
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
other: , EEC Official Journal L 133, Part C: Biodegradability: Activated Sludge: Test for Inhibition of Oxygen Consumption (corresponds for the most part to OECD 209)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
Deviations:
not specified
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Details on test solutions:
test substance was weighed and directly applied into the test medium
Test organisms (species):
activated sludge of a predominantly domestic sewage
Details on inoculum:
no pretreatment, pH before test: 7.9, sludge concentration in test 800.0 mg/L
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
30 min
Test temperature:
20 +/- 2 °C
Nominal and measured concentrations:
Nominal: 10000, 1000 and 100 mg/L
Reference substance (positive control):
yes
Remarks:
3,5-Dichlorphenol
Duration:
30 min
Dose descriptor:
EC50
Effect conc.:
> 10 000 mg/L
Results with reference substance (positive control):
3,5-Dichlorphenol EC50: 19 mg/L
Validity criteria fulfilled:
not specified
Conclusions:
Test item revealed an EC50 of > 10000 mg/l in a respiration inhibition study with activated sludge, measured for 30 minutes (Bayer, 1995).
Executive summary:

4-Trifluormethoxyphenylisocyanate revealed an EC50 of > 10000 mg/l in a respiration inhibition study with activated sludge, measured for 30 minutes (Bayer, 1995).

Description of key information

The toxicity to microorganisms of 4-Trifluormethoxyphenylisocyanate resulted in an EC50 >10000 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:
10 000 mg/L

Additional information