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Diss Factsheets
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EC number: 204-493-5 | CAS number: 121-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth, H.F. et al
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal. Volume 23, Issue 2, page 95
- Reference Type:
- other: Authoritative data base
- Title:
- CESARS Record no.: 209
- Author:
- CESARS database
- Year:
- 2 011
- Bibliographic source:
- CESARS (Chemical Evaluation Search and Retrieval System ); Smyth, H.F., et al. 1962. Range-finding toxicity data. American Ind. Hyg. Assoc. J. 23(6):95-107
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Groups of 4 male New Zealand rabbits (weight 2.5 to 3.5 kg) were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
- GLP compliance:
- not specified
- Test type:
- other: technique similar to the Draize method.
Test material
- Reference substance name:
- N,N-dimethylaniline
- EC Number:
- 204-493-5
- EC Name:
- N,N-dimethylaniline
- Cas Number:
- 121-69-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- N,N-dimethylaniline
- Test material form:
- other: oily
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylaniline
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- New Zealand rabbits (weight 2.5 to 3.5 kg)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Groups of 4 male albino New Zealand rabbits (weight 2.5 to 3.5 kg) were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
- Duration of exposure:
- 24 hrs.
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 692 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Other details not available
- Mortality:
- The LD50 was reported as 1.77 mL/kg, with a standard deviation range of 1.09 to 2.86 mL/kg.
Conversion to mg/kg used the specific gravity of 0.956 at 20/4°C.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours. In this study, lethal dose (LD50) concentration was found to be 1692 mg/kg.
- Executive summary:
The acute toxicity by dermal route was examined on the groups of 4 male New Zealand rabbits. All animals were tested using a technique similar to the Draize method. The dose was placed on clipped skin and retained beneath an impervious plastic film for 24 hours.
The lethal dose (LD50) was found to be 1.77 mL/kg, with a standard deviation range of 1.09 to 2.86 mL/kg. Conversion to mg/kg used the specific gravity of 0.956 at 20/4°C.
Hence, Dermal toxicity of N,N-dimethylaniline (LD50) was found to be 1692 mg/kg body weight. This value indicates that N,N-dimethylaniline is classified as category IV for acute toxicity through dermal route.
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