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Diss Factsheets
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EC number: 271-591-2 | CAS number: 68585-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The rationale to read-across the data is attached in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Nominal and measured concentrations:
- Nominal loading rate: 100 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- No remarkable observations concerning the appearance of the test medium.
The analytically measured concentrations of yttrium oxide in the test medium samples taken at the start and at the end of the test were 528 and 519 µg/L respectively (arithmetic mean = 523 µg/L). The solubility limit reached during this test was thus slightly different from that obtained during the water solubility test (see IUCLID section 4.8). Such contrasting results could be explained by the different water media used in the water solubility test and ecotoxicological studies (media containing analytical grade salts). - Validity criteria fulfilled:
- yes
- Conclusions:
- In a limit test at nominal loading rate of 100 mg/L, yttrium oxide has no acute toxic effect on Daphnia magna up to its solubility limit in the test water (solubility limit concentration determined as 523 µg/L).
This result is read-across to yttrium oxide, europium-doped. - Executive summary:
The 48hr-acute toxicity of yttrium oxide to Daphnia magna was studied under static conditions according to the EU Commission Directive 92/69/EEC, Part C.2 (1992) and the OECD Guideline for Testing of Chemicals, N°202 (2004). Daphnids were exposed to a control and the test chemical at a nominal loading rate of 100 mg /L for 48 hours. Mortality/immobilization were observed daily. No immobility was observed during the 48-h test period, neither in the control, nor at the loading rate of 100 mg/L. The 48 hour LL50 and NOELR were thus > 100 mg/L and >= 100 mg/L, respectively.
This result is read across to yttrium oxide, europium-doped.
Reference
Description of key information
The 48-h LL50 obtained on Daphnia magna for yttrium oxide is > 100 mg/L based on nominal loading rate corresponding to > 523 µg/L based on measured concentration (calculated from arithmetic mean of measured concentrations). Therefore, yttrium oxide is not harmful to aquatic invertebrates up to its solubility limit into water.
Key value for chemical safety assessment
Additional information
The toxicity of the substance itself to aquatic invertebrates was not tested, howver, an acute Daphnia study with the analogue yttrium oxide is available. The justification for read-across using the analogue approach is described in a report (see section 13 of IUCLID).
The 48hr-acute toxicity of yttrium oxide to Daphnia magna was studied under static conditions according to the EU Commission Directive 92/69/EEC, Part C.2 (1992) and the OECD Guideline for Testing of Chemicals, N°202 (2004). Daphnids were exposed to control and test chemical at a nominal loading rate of 100 mg /L for 48 hours. Mortality/immobilization were observed daily. No immobility was observed during the 48-h test period, neither in the control, nor at the nominal loading rate of 100 mg/L, corresponding to 523 µg/L based on measured concentration (calculated from arithmetic mean of measured concentrations). The 48 hour LL50 and NOELR were thus above the water solubility limit or > 100 mg/L and >= 100 mg/L, respectively.
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