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EC number: 249-881-5 | CAS number: 29820-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-11-07 - 2008-05-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Federal State Authority, North Rhine-Westphalia, Germany
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Calcium sulphidoacetate
- EC Number:
- 249-881-5
- EC Name:
- Calcium sulphidoacetate
- Cas Number:
- 29820-13-1
- Molecular formula:
- C2H4O2S.Ca x 3 H2O
- IUPAC Name:
- calcium 2-sulfanidylacetate
- Reference substance name:
- CaTG
- IUPAC Name:
- CaTG
- Test material form:
- aerosol dispenser: not specified
- Remarks:
- migrated information: aerosol
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- CaTG aerosol sampled by gravimetric analysis was eluted from the filter and then determined by HPLC.
- Duration of exposure:
- 4 h
- Concentrations:
- Four groups of rats were nose-only exposed to a solid aerosol in concentrations of 483, 1022, 2208, and 2729 mg/m3 air.
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 729 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Mortality did not occur in any concentration-dependent manner. The particle size distribution was not essentially different between groups with mortality. The LC50 was greater than 2729 mg/m3. No animals died at 483 mg/L (0/10 animals, 4 h exposure).
- Clinical signs:
- other: The signs of importance for the toxicological evaluation of the highest dose group can be qualitatively described as follows: bradypnea, labored breathing patterns, stridor, motility reduced, flaccidity, piloerection, hair-coat ungroomed, nose reddened, a
- Body weight:
- Comparison between control and exposure groups revealed consitent, concentration-dependent decrease in body weights.
- Gross pathology:
- Findings of toxicological importance and for toxicological evaluation can be summarized as follows:
Animals sacrificed at the end of the observation period: The macroscopic findings were essentially indistinguishable amongst exposure and control groups.
Animals succumbing during the observation period: nose-/muzzle area: red encrustations with somewhat occlude nostrils, trachea with white foamy content, lung less collapsed and with dark-red discolorations, gastrointestinal tract: black-red focal discolorations of mucosa and dark-red content in the lumen. - Other findings:
- Statistical comparisons between the control and the exposure groups revealed significant changes in body temperature in groups 3 and above.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The aerosolized CaTG (solid aerosol, dry powder) proved to have a low acute inhalation toxicity in rats. Thus, the LC50 is greater than 2729 mg/m3. However, the observed signs demonstrated that the respirable dust of this test substance (in its micronized form) may cause marked and prolonged respiratory tract irritation.
- Executive summary:
A study on the acute inhalation toxicity of CaTG on rats has been conducted in accordance with OECD Guideline No. 403. Mortality occurred in a few rats at 1022 mg/m3and above. However, any concentration-dependence or particular sex-dependence was not observed. The maximum technically achievable concentration was 2729 mg/m3. The exposure to this exposure level caused lingering and pronounced irritant effects in the upper and lower respiratory tract. Mortality is considered to be linked to acute lung edema. Due to the absence of concentration-dependent changes in particle size, the LC50is greater than the maximum technically attainable concentration. Due to technical aspects as well as animal welfare considerations, the testing of CaTG at around 3000 mg/m3is considered to meet the criteria of limit-test of contemporary testing guidelines.
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