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Diss Factsheets
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EC number: 292-883-6 | CAS number: 91002-07-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Significant methodological deficiencies
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Tierexperimentelle Untersuchungen zur Toxizität des Bariumstearates
- Author:
- Schmidt, P. et al.
- Year:
- 1 975
- Bibliographic source:
- Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 21: 613 - 617.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Determination of the lethal dose of barium stearate by intraperitoneal injection in the abdominal area of rats.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Barium stearate
- IUPAC Name:
- Barium stearate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from own institute random breeding
- Weight at study initiation: 204 g (180 - 220 g)
- Housing: in groups of 10 rats
- Diet: pelletised standard feed (Sorte K) of the Staatlichen Zentralstelle für Versuchstierzucht und - versorgung Berlin
- Water (ad libitum)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- peanut oil
- Details on exposure:
- Intraperitoneal injections of the test substance were given into the lower left side of the abdomen.
- Doses:
- 8 doses (the number of doses was derived from the total number of animals divided by the number of animals used per dose; the doses were not further described)
- No. of animals per sex per dose:
- 10 female rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: the examination of the surviving animals were conducted from 8:00 to 12:00 o'clock, if not otherwise stated.
- The animals were killed through exsanguination after etherisation. - Statistics:
- The lethal dose was calculated according to Litchfield and Wilcoxon (1949)*
* Reference:
Litchfiled, jr., I.T., and W.F. Wilcoxon: J. Pharmacol. exper. Therapeut. 96 (1949), 99.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 850 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 600 - 2 150
- Remarks on result:
- other: LD50 of barium stearate was calculated 8 days after study initiation.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 352 mg/kg bw
- Based on:
- element
- 95% CL:
- 304 - 400
- Remarks on result:
- other: LD50 of barium was calculated 8 days after study initiation.
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Conclusions:
- LD50 (female rats, intraperitoneal injection): 1850 mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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