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EC number: 219-842-7 | CAS number: 2550-02-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28.02.1992 to 21.07.1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- animal husbandry - minor excursions from recommended relative humidity
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triethoxypropylsilane
- EC Number:
- 219-842-7
- EC Name:
- Triethoxypropylsilane
- Cas Number:
- 2550-02-9
- Molecular formula:
- C9H22O3Si
- IUPAC Name:
- triethoxy(propyl)silane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: White Russian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: ASTA Medica AG, Halle-Kűnsebeck, GERMANY
- Age at study initiation: Males: 8 or 12 months; Females: 6 months
- Weight at study initiation: Males: 2.47, 2.49 kg; Females: 2.33 kg
- Housing: 1/ cage. Stainless steel cage with grating floor.
- Diet: standard diet approximately 120 g/day
- Water: drinking water ad libitum
- Acclimation period: at least 1 day
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22 (briefly to 22.5)
- Humidity (%): 50-70 (briefly to 74). The Guideline recommends a maximum of 70%.
- Air changes (per hr): not stated
- Photoperiod (hrs dark / hrs light): 12 /12
IN-LIFE DATES: From: 10 March 1992 to 20 March 1992
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL (neat) - Duration of treatment / exposure:
- Single application without washing; study terminated for last animal after 6 days.
- Observation period (in vivo):
- 1, 24, 48, 72 hours, then daily to day 4 (2 animals) or 6 (1 animal).
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing : no washing
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: pencil light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: mean out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility not applicable
- Irritation parameter:
- iris score
- Basis:
- other: mean out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility not applicable.
- Irritation parameter:
- conjunctivae score
- Basis:
- other: mean out of animal #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- other: mean out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritant / corrosive response data:
- The test material was transiently irritant, see table 1.
Scored at 24, 48 and 72 h it was clear that 2 of 3 animals did not achieve scores that would be indicative of irritation. - Other effects:
- There were no systemic effects.
Any other information on results incl. tables
Table 1: Irritant/corrosive response data for each animal at each observation time
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae - redness |
Conjunctivae- chemosis |
Conjunctivae - discharge |
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
Max. score 3 |
|
60 min |
0/0/0 |
1/0/0 |
3/1/2 |
3/1/1 |
3/3/3 |
24 h |
0/0/0 |
0/0/0 |
2/1/1 |
1/0/0 |
1/0/0 |
48 h |
0/0/0 |
0/0/0 |
2/1/1 |
0/0/0 |
0/0/0 |
72 h |
0/0/0 |
0/0/0 |
1/1/0 |
0/0/0 |
0/0/0 |
Average 24 h, 48 h, 72 h |
0/0/0 |
0/0/0 |
1.7/1/0.7 |
0.3/0/0 |
0.3/0/0 |
Average score (including area affected, max 110)* |
0 |
0.4 |
5.3 |
||
Reversibility** |
n/a |
c |
c |
c |
c |
Maximum time for reversion |
n/a |
24 h |
6 days*** |
48 h |
48 h |
* Scoring ocular lesions: as given in report, based on 1, 24, 48, 72 h
** Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
*** Conjunctival redness was still evident in one animal at day 4.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- In an eye irritation study conducted according to OECD 405 and in compliance with GLP (reliability score 1), triethoxypropylsilane was transiently irritating, with a Draize score of 6 out of 110, and it was therefore concluded that the test substance is not irritating to the eyes.
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