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EC number: 235-285-2 | CAS number: 12158-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test material was sieved in an alpine air jet sieving machine.
- GLP compliance:
- no
- Type of method:
- sieving
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- - solid powder
- Key result
- Percentile:
- D90
- Mean:
- < 100 µm
- Remarks on result:
- other: no standarddeviation was provided.
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- > 90 %
- Conclusions:
- More than 90% of particles were found to be < 100 µm in diameter.
- Executive summary:
More than 90% of particles were found to be < 100 µm in diameter and as such the particle size distribution indicates dicopper hydroxide phosphate is an inhalation risk (a significant proportion of the particles are present at < 100 µm).
This study is considered to be appropriate and reliable for use as a key study in accordance with Regulation (EC) No. 1907/2006 (REACH). No further testing is required.
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 436
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of Inspection: 19-21 July 2011, Date of signature: 31 August 2011
- Type of method:
- cascade impaction
- Type of distribution:
- other: Gravimetric
- Specific details on test material used for the study:
- Sponsor's identification: Dicopper hydroxide phosphate
Description: Pale green powder
Batch number: MV 500
Purity: Neat Substance
Date received: 14 March 2012
Expiry Date: Not supplied
Storage conditions: Room temperature, in the dark - Mass median aerodynamic diameter:
- 3.7 µm
- Geometric standard deviation:
- 2.43
- Percentile:
- D50
- Remarks on result:
- not measured/tested
- Conclusions:
- The Mean Mass Median Aerodynamic Diameter was reported to be 3.70 μm.
- Executive summary:
The Mean Mass Median Aerodynamic Diameter was reported to be 3.70 μm. The inhalable fraction (rat) of the test material, % <4 μm, was 53.6 %, which would allow the test material to reach upper and lower regions of the respiratory tract of the test animal. This study is conducted according to an appropriate guideline and under the conditions of GLP, the study is therefore considered to be acceptable and to adequately satisfy both the guideline requirement and the regulatory requirement as a supporting study for this endpoint.
Referenceopen allclose all
The characteristics of the atmosphere achieved in an acute inhalation study were as follows:
Mean Achieved Atmosphere Concentration (mg/L) |
Mean Mass Median Aerodynamic Diameter (μm) |
Inhalable Fraction (% <4 μm) |
Geometric Standard Deviation |
5.09 |
3.70 |
53.6 |
2.43 |
Description of key information
More than 90% of particles were found to be < 100 µm in diameter.
Additional information
The sieve method used in the company test determined that more than 90% of particles were < 100 µm in diameter and as such the particle size distribution indicates dicopper hydroxide phosphate is an inhalation risk (a significant proportion of the particles are present at < 100 µm).
The results from an acute inhalation study reported the Mean Mass Median Aerodynamic Diameter to be 3.70 μm. The inhalable fraction of the test material, % <4 μm, was 53.6 %, which would allow the test material to reach upper and lower regions of the respiratory tract of the rat. In addition, this also means that a fraction of the particles will be respirable (i.e. reaching the alveoli) in humans.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.