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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 914-103-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data agiven.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicology of Ammonium Sulfate in the Lung.
- Author:
- Pepelko WE et al.
- Year:
- 1 980
- Bibliographic source:
- Bull Environ Contam Toxicol 24: 156-160.
Materials and methods
- Principles of method if other than guideline:
- Guinea pigs were exposed for a single 8 h period. Twenty animals were exposed to a concentration of 800 -900 mg/m³, six to a concentration of 600 -700 mg/m³ and six to a concentration of 500 - 600 mg/m³. The animals were observed for mortality and signs of gross toxicity.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ammonium sulphate
- EC Number:
- 231-984-1
- EC Name:
- Ammonium sulphate
- Cas Number:
- 7783-20-2
- Molecular formula:
- H8N2O4S
- IUPAC Name:
- diammonium sulfate
- Details on test material:
- - Name of test material (as cited in study report): ammonium sulfate
No further data
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Vehicle:
- other: water
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Ammonium sulphate aerosol was generated from an aqueous solution with either one or two Retec nebulizers (Retec Development Laboratory, Portland, Oregon) and dried by mixing with dry air and passing it through a heated glass tube. Two nebulizers were used at concentrations greater than 500 mg/m³. Ammonium sulphate concentration was determined by collecting the aerosol on a Gelman A- E glass fiber filter at a flow rate of 2 L/min for 15 min and weighing the filter. Accuracy of the method was periodically checked by chemical analysis of the filter sample. Particle size was evaluated gravimetrically using an Andersen multi-stage sampler (Andersen Sampler Inc., Atlanta, Georgia).
No further data. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically using an Andersen multi-stage sampler (Andersen Sampler Inc., Atlanta, Georgia)
- Duration of exposure:
- 8 h
- Concentrations:
- 500-600, 600-700, 800-900 mg/m³
- No. of animals per sex per dose:
- 6 -20
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 800 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Mortality:
- Mortality rates:
500-600 mg/m³: 0/6
600-700 mg/m³: 1/6
800-900 mg/m³: 8/20
The animals dying during exposure appeared to do so as a result of acute shock and airway constriction. Any sudden noise or other disturbance was likely to precipitate such an event. After exposure, the survivors recovered without any noticable effect.
Any other information on results incl. tables
0/6, 1/6, and 8/20 animals exposed to an aerosol of the test substance at concentrations of 500 -600, 600 -700, and 800 -900 mg/m³, respectively, died.
Applicant's summary and conclusion
- Executive summary:
Six, 6, and 20 guinea pigs were exposed for 8 hours to an aerosol of the test substance at concentrations of 500 -600, 600 -700, and 800 -900 mg/m³, respectively. The animals were observed for mortality and signs of gross toxicity. 0/6, 1/6, and 8/20 animals exposed to the low, mid, and high concentration, respectively, died. The animals dying during exposure appeared to do so as a result of acute shock and airway constriction. Any sudden noise or other disturbance was likely to precipitate such an event. After exposure, the survivors recovered without any noticable effect.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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