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EC number: 469-500-8 | CAS number: 857035-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 04 December 2006 to 28 June 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: compliant to GLP and testing guideline; adequate coherence between data, comments and conclusions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): R0054002C, synonym IMEXINE OBH
- Physical state: beige to yellow powder
- Purity: 99.7%
- Impurities (identity and concentrations): not indicated
- Purity test date: 20 July 2006
- Lot/batch No.: R0054002C 013 L 001, synonym 0604070001
- Expiration date of the lot/batch: 01 August 2007
- Stability under test conditions: not indicated
- Storage condition of test material: at room temperature and under nitrogen gas
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at each test concentration (except for the control) at the beginning of the test and at T24 hours (fresh solutions used for the solution change). Samples were also taken at T24 hours just before the solution change (stale solutions) and at the end of the test at each test concentration (except for the control).
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Strain: STRAUS-clone 5. Invertebrate crustacean (water flea). Species commonly used in Europe for aquatic toxicity testing and recommended in OECD and EEC guidelines.
origin: Centre Technique du Bois et de l’Ameublement, Paris, France.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 257 to 264 mg/L as CaCO3
- Test temperature:
- Between 20.3°C and 21.1°C
- pH:
- 5.92 to 8.21
- Dissolved oxygen:
- 5.8 to 8.8 mg/L
- Salinity:
- Not measured
- Nominal and measured concentrations:
- 18.8, 37.5, 75.0, 150 and 300 mg/L nominal corresponding respectively to 2.04, 5.24, 21.5, 34.2, 113 and 271 mg/L expressed as geometric means of measured concentrations.
- Details on test conditions:
- Test solutions were changed after 24 hours.
Test water: reconstituted (M4). The pH of this solution was 8.0 ± 0.5; the sum of Ca and Mg ions in the solution was 2.5 mmol/L (molar ratio Ca:Mg was approximately 4:1 and Na:K approximately 10:1); total hardness was generally between 238 and 289 mg/L as CaCO3.
Temperature in water: between 18°C and 22°C and not varying by more than ± 1°C throughout the test, measured using a max-min thermometer.
Light/dark cycle: 16/8 hours.
Duration of test: 48 hours.
Loading: one daphnid for 10 mL of solution.
pH: between 6± 0.2 and 9± 0.2 in all test item solutions after pH adjustement when relevant ( i.e. < 5.8 or > 9.2) .
Forced aeration: not used during the test. Dilution water was aerated prior to the addition of the test item.
Oxygen concentrations: > 3 mg/L at that temperature. - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.49 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL48 h: 5.79 - 11.6 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.04 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Details on results:
- The no observed effect concentration (NOEC) at 48 hours and the highest concentration resulting in no immobilization were 2.04 mg/L, while the 48-hour EC50 of the test item was 8.49 mg/L.
- Results with reference substance (positive control):
- EC50 24 h (potassium dichromate) = 1.39 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a 48-hour semi-static acute toxicity test with Daphnia magna, the EC50 (calculated from geometric means of measured concentrations) of IMEXINE OBH was 8.49 mg/L.
The No Observed Effect Concentration (NOEC) was 2.04 mg/L (geometric mean of measured concentrations).
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