Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 473-810-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 August 2005 to 27 October 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 5.49 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 96 h
- Temp.:
- 20 °C
- pH:
- 3.9
- Details on results:
- The test was performed at 20.0 ± 0.5 °C in vessels protected from light. The solubility in water was found to be 5.49 ± 0.16 g/L with a precision of 3 %. In the three replicate solutions prepared, the pH values were found to be 3.86 for Replicate 1, 3.94 for Replicate 2 and 3.91 for Replicate 3. Detailed results are presented in Table 1.
The resulting saturated solutions were acidic and colourless. - Conclusions:
- Under the conditions of this study, the solubility of the test material in water was found to be 5.49 ± 0.16 g/L (CV = 3 %) at 20.0 ± 0.5 °C.
- Executive summary:
The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions.
The water solubility of the test material was first evaluated in a preliminary test indicating a solubility value above 10 mg/L. The final determination of water solubility was therefore undertaken using the flask method.
Aliquots (approx. 4.99 g) of the test material were mixed with approximately 100 mL of Milli-Q water in a bottle flask protected from light. The solutions were agitated in a water bath at 30 °C using a magnetic stirrer. After 24 hours (Replicate 3), 48 hours (Replicate 2) and 72 hours (Replicate 1), in an attempt to achieve a saturation mass concentration, replicates were cooled to 20.0 ± 0.5 °C in a water bath for 24 hours. Solutions were analysed sing HPLC with UV detection. For each replicate, pH values of the solutions were measured on a sample of saturated solution. The resulting saturated solutions were acidic and colourless.
Under the conditions of this study, the solubility of the test material in water was found to be 5.49 ± 0.16 g/L (CV = 3 %) at 20.0 ± 0.5 °C.
Reference
Table 1: Water solubility of the test item (flask method at 20.0 ± 0.5 °C)
Replicate number / Sampling time |
Water solubility (g/L) |
|||
First dilution |
Second dilution |
Mean (n = 2) |
Mean (n = 6) |
|
3 / T 48 h |
5.49 |
5.58 |
5.54 |
|
2 / T 72 h |
5.24 |
5.39 |
5.32 |
|
1 / T 96 h |
5.51 |
5.71 |
5.61 |
|
|
5.49 |
|||
SD |
0.16 |
|||
CV % |
3 |
Description of key information
Under the conditions of this study, the solubility of the test material in water was found to be 5.49 ± 0.16 g/L (CV = 3 %) at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 5.49 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105 and EU Method A.6 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The water solubility of the test material was first evaluated in a preliminary test indicating a solubility value above 10 mg/L. The final determination of water solubility was therefore undertaken using the flask method.
Aliquots (approx. 4.99 g) of the test material were mixed with approximately 100 mL of Milli-Q water in a bottle flask protected from light. The solutions were agitated in a water bath at 30 °C using a magnetic stirrer. After 24 hours (Replicate 3), 48 hours (Replicate 2) and 72 hours (Replicate 1), in an attempt to achieve a saturation mass concentration, replicates were cooled to 20.0 ± 0.5 °C in a water bath for 24 hours. Solutions were analysed sing HPLC with UV detection. For each replicate, pH values of the solutions were measured on a sample of saturated solution. The resulting saturated solutions were acidic and colourless.
Under the conditions of this study, the solubility of the test material in water was found to be 5.49 ± 0.16 g/L (CV = 3 %) at 20.0 ± 0.5 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.