4-amino-2-fluorobenzamide

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 Feb 2022

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2022

Report date:

2022

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

4-Amino-2-fluoro-benzamide

EC Number:

809-434-2

Cas Number:

609783-45-1

Molecular formula:

C7H7FN2O

IUPAC Name:

4-Amino-2-fluoro-benzamide

Results and discussion

Vapour pressure

Key result

Test no.:

#1

Temp.:

20 °C

Vapour pressure:

0 Pa

Remarks on result:

other: mean of three measurements

Any other information on results incl. tables

The measurement of the vapour pressure was performed in the temperature range between 100 °C and 140 °C. For the evaluation, the reproducible weight loss values above 1 µg/min of the temperature steps between 110 °C and 130 °C have been considered.

The plot of log V_T of the test item as function of the reciprocal temperatures. The coefficient of correlation (R²) was 0.9863.

Inserting the equation for log V_T above, the following equation for the temperature dependence of the vapour pressure of the test item is obtained:

logPT = 5.1909 + 1.1972 * (-5216.2 * 1/T + 9.7485)

With this equation, the following vapour pressure results were obtained:

3.53 ∙ 10^-5 Pa at 20 °C resp. 8.05 ∙ 10^-5 Pa at 25 °C.

 

 

 

Applicant's summary and conclusion

Conclusions:

The isothermal thermogravimetrical effusion method was applied for the deter-mination of the vapour pressure of the test item.
A value of the vapour pressure of the test item was assessed using the data ob-tained between 110 °C and 130 °C. The vapour pressure of the test item was estimated to be
3.53 x 10-5 Pa at 20 °C resp. 8.05 x 10-5 Pa at 25 °C.

Executive summary:

Test Design: The vapour pressure of the test item at 20 °C und 25 °C (P_T, 20 resp. P_T, 25) was determined using the isothermal thermogravimetrical effusion method. According to the guideline, this method was validated in the range 10^-10 to > 1 Pa using a set of reference substances with known vapour pressures. 

Results/Conclusion: The isothermal thermogravimetrical effusion method was applied for the determination of the vapour pressure of the test item. A value of the vapour pressure of the test item was assessed using the data obtained between 110 °C and 130 °C. The vapour pressure of the test item was estimated to be 3.53 x 10^-5 Pa at 20 °C resp. 8.05 x 10^-5 Pa at 25 °C.