4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 Nov 1995

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The concentration of the test substance in the test solution was not analytically determined. However, the water solubility of the test substance was approximated to the upper concentration range of the test (c>1000 g/L). Therefore, the values determined within this study for water solubility were considered valid.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

92/69/EEC

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

> 1 000 g/L

Conc. based on:

test mat.

Remarks:

concentration based on nominal concentration

Loading of aqueous phase:

1 000 g/L

Incubation duration:

1 h

Temp.:

20 °C

Remarks on result:

other: The concentration of the test substance in solution was not analytically determined

Validity criteria for the measurement of the water solubility:

Target condition according to guideline 92/69/EWG A.6:	Actual condition according to the study:	Validity criteria met:
The individual results from each of the three flasks, which should not differ by more than 15%, are averaged.	In the study two flasks were used for the test. The pretest on the density showed that the test substance is completely miscible with water (d20=1109 kg/m^3). Therefore, two flasks were considered sufficientto to assign the solutiblity of the test substance to the upper concentration range (>1000 g/L) of this test.	Yes
A substance-specific analytical method is preferred for these determinations, since small amounts of soluble impurities can cause large errors in the measured solubility. Examples of such methods are: gas or liquid chromatography, titration methods, photometric methods, voltametric methods.	No analytical determination were done within the study. However, the water solubility of the test substance was approximated to the upper concentration range of the test (c>1000 g/L). Therefore, the values determined within this study for water solubility were considered valid.	No

Conclusions:

The water solubility of the test substance in the preliminary test was determined to be >1000 g/L.

Executive summary:

The study was performed to determine the water solubility of the test substance by the flask method in accordance with EC Testing Guideline A.6. A pretest on the density of the test substance showed that the test substance is completely miscible with water (d20=1109 kg/m3). Therefore, a preliminary test given in the Testing Guideline was used to assign the solubility of the test substance to the upper concentration range (c>1000 g/L). Two volumetric flasks, each containing approximately 2 g (1.8 mL) of the test substance were used for determinations at 20 °C. To obtain, the exact volume of the solution their density was determined at 20°C with an oscillating density meter. The solubility of the test substance at 20°C was approximated to be >1000 g/L.

Description of key information

A study was performed to determine the water solubility of the test substance by the flask method in accordance with EC Testing Guideline A.6. A pretest on the density of the test substance showed that the test substance is completely miscible with water (d20=1109 kg/m3). Therefore, a preliminary test given in the Testing Guideline was used to assign the solubility of the test substance to the upper concentration range (c>1000 g/L). Two volumetric flasks, each containing approximately 2 g (1.8 mL) of the test substance were used for determinations at 20 °C. To obtain, the exact volume of the solution their density was determined at 20°C with an oscillating density meter. The solubility of the test substance at 20°C was approximated to be >1000 g/L.

Key value for chemical safety assessment

Water solubility:

1 000 g/L

at the temperature of:

20 °C