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EC number: 203-950-6 | CAS number: 112-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Studies using 14-carbon labelled trientine (TETA) given to rats indicate that only some 20% of the drug is absorbed from the gut. It was detected in all tissues analysed, with a maximum concentration in the kidneys. It is rapidly excreted in the urine and more slowly in the bile. There is no evidence that the compound is broken down in the body, but biotransformation does occur, probably by acetylation and possibly other forms of conjugation. The conjugates can all be converted back to trientine by acid hydrolysis (Gibbs, 1986).
A study on dermal absorption concluded that " Triethylenetetraamine is not absorbed through the skin to any appreciable extent" (Oyen, 1953).
Another study, on carcinogenicity (DePass 1987), states "Although no skin penetration studies were performed with these ethyleneamines, such studies were performed in the rat with EDA. The results indicated that the rate of absorption was concentration dependent and relatively slow following topical application (Yang et al.,1983a). The estimated absorption was 55 and 12% respectively, when 25 and 10% aqueous solutions were applied for 24 hr. Because of the higher weights and greater number of potentially positively charged amino groups of these ethyleneamines compared to EDA, it is likely that there was very limited systemic circulation of the compounds in these studies. This would be consistent with the absence of systemic toxic effects”
It is therefore concluded that TETA is poorly absorbed after oral administration and very poorly, if at all, absorbed after dermal application. If absorbed, it is rapidly metabolized and excreted.
Other studies were done with TETA.2HCl (CAS 38260 -01 -4). The 8 -h TETA excretion by 2 subjects was only 1.6 and 1.7%, respectively, of the administered dose. This finding apparently suggested that TETA was hardly absorbed through the digestive tract (Kodoma 1993). This was supported by Kobayashi (1990) showing that the bioavailability of TETA was below 10% and the plasma levels of TETA in non-fasted rats were significantly lower than that observed in fasted rats. The urinary excretion of unchanged TETA during 24 h was only 3.5% of the orally administered dose. However, the urinary excretion of total TETA including metabolites, though they have not been identified, was 35.7%. These results suggest that low bioavailability of TETA might be due to the rapid metabolism in the body after absorption from the gastrointestinal tract. Bioavailability of 25.5% in rats in a fasting state and 14.0% in rats not in a fasting state was also reported (Takeda 1995). The main absorption route for TETA might be permeation across the plasma membrane of intestinal epithelial cells, brush border membrane (BBM) of rat small intestine (Kobayashi 1990). The concentration of dosage solution and first pass metabolism in the intestinal wall may play an important role in the absorption of TETA in humans as well as in rats (Takeda 1995). Tanabe (1996a) showed that the predominant transport process of polyamines in rat intestinal brush-border membrane seemed to be passive diffusion which is dependent on the electrostatic binding to the acidic phospholipids such as phosphatidylserine. The uptake of TETA by rat intestinal brush-border membrane vesicle shares with polyamine a common transport mechanism which includes a charge-interaction between the polycation and the negative charge of the inner membrane layer. This mechanism provides an explanation for the poor and variable absorption of TETA. A study with beagle dogs showed that no significant accumulation of TETA occurred during the dosing period (Meamura 1998).
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