2H-Pyran-2-one, tetrahydro-5-pentyl-

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Test dates: 2005-11-24 to 2006-02-22

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. Deviation in test conditions may affect the accuracy. The substance is considered adequately characterised. Therefore validation applies with restrictions.

Qualifier:

according to guideline

Guideline:

EU Method A.8 (Partition Coefficient - Shake Flask Method)

Deviations:

yes

Remarks:

maximum phase concentration exceeds 0.01 M

GLP compliance:

yes (incl. QA statement)

Remarks:

issued 2006-02-24

Type of method:

flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Storage condition of test material: room temperature protected from direct sunlight.

Analytical method:

gas chromatography

Key result

Type:

log Pow

Partition coefficient:

2.4

Temp.:

20 °C

Remarks on result:

other: The pH of the aqueous phases was not recorded.

ratio	ratio 1:10		ratio 2:10		ratio 1:20
replicate vessel	1	2	1	2	1	2
log Kow	2.35	2.40	2.37	2.38	2.39	2.43
mass balance	97.1%	98.9%	98.8%	94.9%	96.1%	100.2%

Mean Log Pow and standard deviation = 2.39 ± 0.03

The observed interval within the six LogPow values was [2.35 - 2.43] and the validity criterion was fulfilled: The six LogPow values fell within a range of less than ± 0.3 units.

Conclusions:

The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4 ).

Executive summary:

The partition coefficient of the test substance was determined under GLP according to EU A.8 guideline, flask method.

Determinations were conducted in duplicate for three solvents ratio (1:10, 1:20 and 2:10, 2 replicates each), concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.

The log Kow was determined to be 2.4 at 20°C.

Description of key information

The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.

The substance has low potential for bioaccumulation (log Kow <4).

Key value for chemical safety assessment

Log Kow (Log Pow):

2.4

at the temperature of:

20 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available.

Despite restrictions due to deviation in test conditions, it is considered as a key study, and the result is retained as key data.