(2RS,3RS)-3-(2-chlorophenyl)-2-(4-fluorophenyl)-[(1H-1,2,4-triazol-1-yl)methyl]oxirane

Sediment toxicity

Description of key information

The 28 -d NOEC (initial measured, emergence and development) was determined to be > = 674.5 µg/kg sediment dw in an OECD 218 GLP-guideline test with Chironomus riparius (Backfisch, 2008)

The 21 -d NOEC (nominal, analytically verified, emergence) was determined to be > 0.0625 mg/L in an OECD 218 GLP guideline test with Chironomus riparius, water-spiked (BASF AG, 1995)

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater sediment:

674.5 µg/kg sediment dw

Additional information

The sediment organism Chironomus sp. was exposed to Epoxiconazole and the number of emerged animals as well as signs of intoxication of the animals was recorded during a test period of 28 days. The test was set up according to OECD guideline 218 with artificial sediment. Analytical verification of test item concentrations was conducted in each concentration. Recoveries in the sediment were in a range between 90.5% - 106.6% of the nominal concentrations at test initiation. The following initial concentrations were measured: 113.1, 183.4, 269.2, 402.5 and 674.5 µg/kg dry sediment. At test termination the detected concentrations ranged from 85.4% - 98.6%. The biological results are based on initial measured concentrations. A 28 -d NOEC of >= 674.5 µg/kg sediment was determined (initial measured, emergence and development; Backfish, 2008).

In addition, a GLP study conducted according to OECD 218 (water-spiked) is also available for epoxiconazole. In a 21-day static, spiked water toxicity laboratory study, Chironomus riparius were exposed to nominal concentrations of 0.00625 and 0.0625 mg/L. The endpoint derived in this study was the 21-days NOEC ≥ 0.0625 mg/L. Since no effects up to the highest test concentrations were observed, no ECx calculations are possible. The test concentrations were analytically measured in both studies.