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EC number: 209-513-6 | CAS number: 583-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 14 2017 - January 18 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Remarks:
- The preparation of a sample of the aerobic sludge was a mixture of treatment plant of urban (about 66%) and industrial (about 34%) liquid sewage located in Monza Italy.
- Duration of test (contact time):
- ca. 10 - ca. 28 d
- Initial conc.:
- 33.39 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- TOC removal
- Details on study design:
- The study was conducted in the Eurofins Biolab S.r.l. Test Facility, Vimodrone (Ml) - Italy, Via Bruno Buozzi, 2.
EXPERIMENTATION: Aerobic Biodegradability of organic compounds in aqueous medium
START: December 14th, 2017
END: January 18th, 2018
RESEARCHER: D. Facchetti
- OECD 310 - 2014. Ready Biodegradability - C02 in sealed vessels (Headspace Test)
- EN ISO 10634:1995 - Guidance for the preparation and treatment of poorly water soluble organic compounds for the subsequent evaluation of their biodegradability in an aqueous medium. - Reference substance:
- other: 1-octanol
- Key result
- Parameter:
- % degradation (TOC removal)
- Value:
- 78
- Sampling time:
- 7 d
- Details on results:
- EXPRESSION OF RESULTS
The calculation of biodegradation is done at each sampling time for the reference substance, test sample and blank.
Total biodegradation has been calculated using the equation:
D=(TIP-TIC)/TOC*100
Where:
D = total biodegradation calculated with reference to values of blank, expressed in percentage. TIC, = concentration of inorganic carbon, in mg, produced by biodegradation of the test item.
TIC = concentration of inorganic carbon, in mg, produced by biodegradation in blank.
TOC = concentration of organic carbon of the test item, in mg, added at the beginning.
The result of biodegradability is expressed as the percentage ratio between the value of inorganic carbon measured and the value of organic carbon added at the beginning. The value of inorganic carbon is the highest value recorded during 28 days of experimental period
INTERPRETATION OF RESULTS
The test is considered valid when:
- the percentage of average degradation of the reference substance is more than 60% after 14 days of incubation.
-the mean amount of TIC present in the blank at the end of the test is < 3 mg C/L.
A substance is considered biodegradable when its level of biodegradability is at least 60%, within a period of 28 days.
A substance is considered readily biodegradable when its level of biodegradability is at least 60%, within 10d window during the test.
If, at day 28, the biodegradation in the bottle contained both the test sample and the reference substance referred to biodegradation in the bottle with reference substance result < 25%, it may be assumed that the test substance don't inhibited the activity of the inoculum.
If in the bottle to check abiotic biodegradation a significant increase (>10%) in the amount of TIC is observed, abiotic degradation processes may have occurred.
RESULTS
Quality criteria of the test are satisfied (see table below and Attachment N. 2). Temperature has remained in the range required by the guideline (20 ± 1 °C).
The mean amount of TIC present in the blank controls at the end of the test is <3 mg C/L.
The vessels show < 20% difference and no outliers have been observed. The trend of the inorganic carbon and related biodegradation percentages in the bottle contained both the test sample and the reference substance confirm the absence of inhibitory effect of the test sample on inoculum (<25%). - Results with reference substance:
Check Point (Days) and % OF BIODEGRADATION Reference substance
0 and 0,
1 and 4,
7 and 105,
14 and 113,
21 and 89,
28 and 98- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- On the basis of results obtained, interpreted in accordance to OECD 310: 2014, the test item 2-methylcyclohexanone is considered readily biodegradable in aerobic conditions
Reference
Check Point (Days) | % OF BIODEGRADATION Reference substance | % OF BIODEGRADATION Test substance | % OF BIODEGRADATION Reference substance + Test substance |
0 | 0 | 0 | 0 |
1 | 4 | 1 | 1 |
7 | 105 | 78 | - |
14 | 113 | 78 | - |
21 | 89 | 68 | - |
28 | 98 | 90 | 86 |
Description of key information
On the basis of results obtained, interpreted in accordance to OECD 310: 2014, the test item 2-methylcyclohexanone is considered readily biodegradable in aerobic conditions
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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