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EC number: 415-890-1 | CAS number: 142770-42-1 QUANTACURE CPTX
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January - March 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Version / remarks:
- 1985
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-chloro-4-(n-propoxy)-5-thioxanthen-10-one
- EC Number:
- 415-890-1
- EC Name:
- 1-chloro-4-(n-propoxy)-5-thioxanthen-10-one
- Cas Number:
- 142770-42-1
- Molecular formula:
- C16H13ClO2S
- IUPAC Name:
- 1-chloro-4-propoxy-9H-thioxanthen-9-one
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield UK
- Age at study initiation: 10-12 weeks
- Weight at study initiation: 2.3 - 2.9 kg
- Fasting period before study:
- Housing: individually in metal cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/-3 °C
- Humidity (%): 30-70%
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Vehicle:
- corn oil
- Remarks:
- CPTX was prepared at a maximum practical concentration of 80% w/v in corn oil
- Details on dermal exposure:
- Test substance was prepared on the day of dosing.
One day prior to treatment hair was removed from the dorso-lumbar region of each rabbit with electric clippers exposing an area equivalent to approx. 10% of the total body surface.
TEST SITE
- Area of exposure: 50 mm x 50 mm
- The treated area was promptly covered with gauze which was held in place with an impermeable dressing encircled firmly around the trunk.
REMOVAL OF TEST SUBSTANCE
- Washing : At the end of the 24 hours exposure period, the dressings were carefully removed and the treated area of skin was washed with warm water and blotted with absorbent paper.
- Time after start of exposure:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.5 ml/kg bw
- Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg/ bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: twice daily for any mortality. once daily for clinical signs. Bodyweight on day 1, 8 and 15.
- Necropsy of survivors performed: yes (macroscopic examination) - Statistics:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No death
- Clinical signs:
- other: No systemic reaction to treatment. A residual staining from the test substance was noted at all treatment sites following removal of the dressings. Transient slight to well-defined irritation (erythema with or without oedema) was observed at the majority
- Gross pathology:
- Macroscopic examination at study termination revealed a greasy whitish film on the surface of the spleen in three animals and in two of these animals the spleen was also considered to be slightly enlarged. Among remaining animals terminal autopsy revealed no macroscopic abnormalities with the exception of a unilateral hydronephrosis of the kidneys apparent in one female. As a low incidence of this abnormality occurs spontaneously this finding was not considered to be related to treatment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal dermal dose to rabbits of CPTX was found to be greater than 2000 mg/kg bw.
- Executive summary:
A study was performed to assess the acute dermal toxicity of CPTX to the rabbit. A group of ten rabbits (5 males and 5 females) was given a single dermal application to the test substance, formulated in corn oil at a maximum practical concentration of 80% and administered at a dose level of 2000 mg/kg bw. All animals were killed and examined macroscopically on Day 15 (the end of the observation period). There were no deaths and no sign of systemic reaction to treatment. Transient slight to well-defined irritation (erythema with or without oedema) was observed at the majority of treatment sites following removal of the dressings and persisting in the occasional animal through to Day 7. In addition, desquamation at the treatment site , observed in five animals, was first noted in one animal on Day 5 and last seen on Day 13. There were no other dermal changes and reactions had resolved in all instances by Day 14.
A slight bodyweight loss was recorded for one female on Day 8. All other rabbits showed satisfactory bodyweight gains throughout the study.
Macroscopic examination at study termination revealed a greasy whitish film on the surface of the spleen in three animals and in two of these animals the spleen was also considered to be slightly enlarged. Among remaining animals terminal autopsy revealed no macroscopic abnormalities with the exception of a unilateral hydronephrosis of the kidneys apparent in one female. As a low incidence of this abnormality occurs spontaneously this finding was not considered to be related to treatment.
The acute lethal dermal dose to rabbits of CPTX was found to be greater than 2000 mg/kg bw.
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