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EC number: 264-980-3 | CAS number: 64628-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18-March-2002 to 03-April-2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-chloro-N-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]benzamide
- EC Number:
- 264-980-3
- EC Name:
- 2-chloro-N-[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]benzamide
- Cas Number:
- 64628-44-0
- Molecular formula:
- C15H10ClF3N2O3
- IUPAC Name:
- 3-(2-chlorobenzoyl)-1-[4-(trifluoromethoxy)phenyl]urea
- Test material form:
- solid: particulate/powder
- Remarks:
- Appearance: white powder
1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were approximately ten weeks of age when treatment was administered. Feed (PMI Certified Rodent Diet 5002) was provided continuously for ad libitum consumption during the acclimation period and throughout the study prior to dosing (with the exception of the overnight fasting period), as was tap water. Feed and water were periodically sampled and analyzed for a variety of potential impurities. Upon receipt, animals were examined and sacrificed if general appearance and/or behavior were considered abnormal. Those animals considered acceptable were individually housed in single cages and acclimated to their ambient laboratory conditions (set for a temperature of 19° to 25°C (66° to 77°F), relative humidity 30-70%, 12-hr light/dark cycles, an average of at least 11 air changes per hour) prior to placement on the study. For the holding period, animal care personnel observed the animals at least once daily for moribundity and mortality. One animal was sacrificed due to moribundity.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- deionized water
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6 animals per sex per dose
- Control animals:
- yes
- Remarks:
- vehicle only
- Details on study design:
- The oral route of exposure was employed in general accordance with the test guidelines for an acute oral toxicity study, based on this being a possible route of human exposure. Doses were prepared by weighing and mixing the appropriate quantity of Triflumuron and vehicle (10 mL/kg deionized water). Control and treated rats were treated in an identical manner, except controls received vehicle only. Each dose group consisted of 6 animals/sex. Dosing preparations (test substance plus vehicle) were stirred continuously during the dosing process and were administered as a single oral dose, utilizing appropriate dosing equipment, after which the animals were returned to their cages. Animals were sacrificed on Day 14. Dose amounts were based on individual body weights determined on Day 0 (day of exposure).
Cage-side observations were conducted at least once daily for mortality or clinical signs of moribundity with the following exception; On Day 12, animals were not observed for mortality, moribundity. No animals were sacrificed due to moribundity. Detailed physical examinations for clinical signs were carried out at least twice daily for three days (Day 0, 1 and 2) and once daily thereafter through Day 14 with the following exceptions; On Day 4, all animals were observed, however, observations for the female 5000 mg/kg level were not recorded, and on Day 12 animals were not observed for clinical signs of toxicity. These examinations were performed at approximately the same time of day. Body weight determinations were performed weekly. - Statistics:
- Not required
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: other: There were no mortalities or compound-related clinical signs in the control or 5000 mg/kg dose groups. Clinical signs unrelated to the test compound included rough coat and thinning hair.
- Gross pathology:
- Gross observational findings consisted of alopecia in one control male.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- As no mortality was observed, an LD50 of greater than 5000 mg/kg was established in male and female rats following acute oral exposure to triflumuron.
- Executive summary:
In a study performed to GLP and OECD 401, triflumuron formulated in deionised water (10 mL/kg bw) was administered to groups of fasted male and female rats by single gavage dose. Rats were observed for 14 days. The administration of triflumuron did not elicit any treatment-related findings in mortality, clinical signs, body weight and macroscopic pathology. The acute oral LD50 of triflumuron was therefore found to be >5000 mg/kg bw.
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