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Diss Factsheets
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EC number: 942-492-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish life cycle toxicity
- Type of information:
- (Q)SAR
- Remarks:
- The substance is a complex UVCB. Test data for the substance was not available; hence, QSAR modelling was used to assess the toxicity to fish.
- Adequacy of study:
- weight of evidence
- Study period:
- 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on the predictive model PetroTox and for the other polar constituents, a combination of available data in literature and the use of QSAR modelling with ECOSAR (2.0)
- Justification for type of information:
- The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v.4). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The other polar constituents of the substance were assessed using predicted toxicity data from ECOSAR 2.0 made available by the EPA. ECOSAR groups structurally similar organic chemicals with available experimental effect levels that are correlated with physicochemical properties in order to predict toxicity of new or untested industrial chemicals. - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 4). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The other polar constituents of the substance were assessed using predicted toxicity data from ECOSAR 2.0 made available by the EPA. ECOSAR groups structurally similar organic chemicals with available experimental effect levels that are correlated with physicochemical properties in order to predict toxicity of new or untested industrial chemicals. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Remarks on exposure duration:
- Chronic; QSAR
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 1.69 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Conclusions:
- A NOEL of 1.69 mg/L can be considered as the chronic toxicity value of naphtha in fish.
- Executive summary:
The substance, which is designated in this report as ‘naphtha’, is a complex UVCB consisting of a combination of different hydrocarbon constituents with a range of different molecular weights and structures. As test data for the substance was not available, QSAR modelling was used to assess the toxicity to fish for this substance. For the hydrocarbon fraction the predictive model PetroTox, made available by CONCAWE was used, and for the other polar constituents, a combination of available data in literature and the use of QSAR modelling with ECOSAR (2.0) from the EPA was used.
Using hydrocarbon blocks divided up into 16 chemical classes, representative structures are chosen by the software based on similarities in chemical composition. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. Within naphtha (EC 942-492-8), in the specific case of the substance C8-alkyne (unspecified isomer) 0.47% could not be placed in any of the specific hydrocarbon classes within the PETROTOX software, as such the concentration of this constituent was assigned to the C8 i-olefins block.
The simulation was performed using the default parameters of the PETROTOX software with a 10% headspace volume to account of volatilisation of some constituents. In addition, particulate organic carbon level was set at 0.05 mg/L for fish toxicity testing based on value reported in published papers (Redman et al., 2017).
A NOEL of 1.69 mg/L can be considered as the chronic toxicity value of naphtha in fish.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Remarks:
- Predicted value
- Effect concentration:
- 1.69 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.