Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 3.7 - <= 7.81
- Temp.:
- 30 °C
- pH:
- 7.3
- Details on results:
- The HPLC separated multiple components with log Pow values ranging from 3.7 to 7.81. LogPow values for individual components are given in Table 5.
- Conclusions:
- The test substance is a mixture of components with logPow values ranging from log Pow 3.7 to 7.81.
- Executive summary:
The partition coefficient of the test material was determined by an HPLC method, following the procedure in EU method A.8. The results indicated the test substance is a mixture of several components with log Pow values ranging from 3.7 - 7.81. The logPow values of the components were determined by interpolation from a calibration curve constructed from a plot of log k vs.log Pow using reference standards recommended in the guideline.
The distribution of logPow values by peak area % is:
logPow
Area %
3.7
0.95
4.26
40.65
4.77
6.15
5.89 – 7.81
52.25
Reference
Results for the definitive test are shown below:
Table 5. Retention Times, Capacity Factors and logPow Values for Test Substance
Injection 1 |
Injection 2 |
Mean |
Capacity factor (k) |
Log10k |
Log10Pow |
|||
Retention time (mins) |
% |
Retention time (mins) |
% |
Retention time (mins) |
% |
|||
5.73 |
1.0 |
5.728 |
0.9 |
5.729 |
0.95 |
1.28 |
0.11 |
3.7 |
6.548 |
40.6 |
6.548 |
40.7 |
6.548 |
40.65 |
1.61 |
0.21 |
4.26 |
7.521 |
6.3 |
7.522 |
6.0 |
7.522 |
6.15 |
2.00 |
0.3 |
4.77 |
10.4-19.8 |
52.1 |
10.4-20.1 |
52.4 |
10.4-20.0 |
52.25 |
3.15-6.97 |
0.50-0.84 |
5.89-7.81 |
HPLC chromatograms are attached as Figure 2
Description of key information
The test substance is a mixture of components with logPow values ranging from log Pow 3.7 to 7.81.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.26
- at the temperature of:
- 30 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
