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EC number: 242-440-8 | CAS number: 18599-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 January 1980 - 22 February 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Justification for type of information:
- Although a subacute study is not typically used to determine an acute inhalation classification, this study included concentrations 4 times above the current recommended toxicity testing limit. The exposure concentrations were measured, and rats were treated for 6 hours per day. Since no mortality or significant clinical signs beyond narcosis were noted, this study is considered sufficient to support a STOT SE 3 classification. Pathology examinations and clinical chemistry measurements were also included in the study allowing a reliable prediction of no classification for acute toxicity by inhalation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: to observe the effects of the test substance - BTFB on male rats after repeated inhalation exposures over a 2 week period.
- Short description of test conditions: Male Crl:CD rats were exposed to BTFB at 0.10% or 1.03% in air with the control group exposed to air only for 6hrs/day, 5 days/week for 2 weeks. Clinical observations were made throughout the testing period with clinical chemical analyses performed following 10th exposure. Pathological examinations performed following necropsy with body and organ weigh analysis performed.
- Parameters analysed / observed:Clinical observations, pathological analysis, clinical chemistry, body weight - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-bromo-3,3,4,4-tetrafluorobut-1-ene
- EC Number:
- 242-440-8
- EC Name:
- 4-bromo-3,3,4,4-tetrafluorobut-1-ene
- Cas Number:
- 18599-22-9
- Molecular formula:
- C4H3BrF4
- IUPAC Name:
- 4-bromo-3,3,4,4-tetrafluorobut-1-ene
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Remarks:
- via glass exposure chambers
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Glass exposure chambers
- Method of holding animals in test chamber: Not stated
- Source and rate of air: Not stated
- Method of conditioning air: Not stated
- System of generating particulates/aerosols: Not stated
- Temperature, humidity, pressure in air chamber: Temperature = less than or equal to 30˚C, Atmosphere = greater than or equal to 19%
- Air flow rate: Not stated
- Air change rate: Not stated
- Method of particle size determination: Not stated
- Treatment of exhaust air: Not stated
TEST ATMOSPHERE
- Brief description of analytical method used: Test item vapours were analysed on a HP 5700A GC with flame ionised detector and an injection splitter.
- Samples taken from breathing zone: yes
VEHICLE (if applicable)
- Justification for use and choice of vehicle: Not stated
- Composition of vehicle: Air
- Type and concentration of dispersant aid (if powder): N/A
- Concentration of test material in vehicle: 0.1% and 1%
- Lot/batch no. of vehicle (if requir - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC with flame ionisation detector
- Duration of exposure:
- 6 h
- Remarks on duration:
- 5 days a week for 2 weeks
- Concentrations:
- 1% = 84650 mg/m3 = 84.65 mg/L
0.1% = 8465 mg/m3 = 8.465 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Remarks:
- 0% concentration
- Details on study design:
- - Dose selection rationale: Not stated
- Rationale for animal assignment (if not random): Not stated
- Fasting period before blood sampling for clinical biochemistry: Not stated
- Rationale for selecting satellite groups: Not stated
- Post-exposure recovery period in satellite groups: Not stated
- Section schedule rationale (if not random): N/A
- Other: N/A
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 84 650 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- none
- Clinical signs:
- other: decreased response to sound and loss of coordination.
- Body weight:
- The mean body weights of animals exposed to test material at 1.0% were significantly lower than those in the control group from exposure 5 through to the recovery period. Rats showed normal rate of weight gain during the recovery period.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.