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EC number: 208-865-8 | CAS number: 544-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- from 16 September 2020 to 22 September 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Study period:
- from 16 September 2020 to 22 September 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC method MT 181
- Deviations:
- no
- GLP compliance:
- yes
- Key result
- Medium:
- n-octanol
- Solubility:
- < 0.001 g/L
- Temp.:
- 20 °C
- Test substance stable:
- not determined
- Conclusions:
- The n-octanol solubility of the test item has been determined to be less than 1.4 x 10-3 g/L at 20.0 ± 0.5 °C.
- Executive summary:
The determination was carried out using Method CIPAC MP 181.
The solubility in n-octanol for Copper diformate hase been determined to be 0.0014 g/L at 20°C.
Sample |
Amount of test item (g) |
Concentration (mg/L) |
Observations |
1 |
0.00014 |
1.4 |
Clear colorless liquid containing undissolved excess test item |
2 |
0.00015 |
1.5 |
Clear colorless liquid containing undissolved excess test item |
3 |
0.00065 |
6.5 |
Clear colorless liquid containing undissolved excess test item |
4 |
0.00060 |
6.0 |
Clear colorless liquid containing undissolved excess test item |
5 |
0.00096 |
9.6 |
Clear colorless liquid containing undissolved excess test item |
6 |
0.00114 |
11.4 |
Clear colorless liquid containing undissolved excess test item |
7 |
0.00209 |
20.9 |
Clear colorless liquid containing undissolved excess test item |
8 |
0.00194 |
19.4 |
Clear colorless liquid containing undissolved excess test item |
9 |
0.00533 |
53.3 |
Clear colorless liquid containing undissolved excess test item |
10 |
0.00530 |
53.0 |
Clear colorless liquid containing undissolved excess test item |
11 |
0.01043 |
104 |
Clear colorless liquid containing undissolved excess test item |
12 |
0.01035 |
104 |
Clear colorless liquid containing undissolved excess test item |
- Reason / purpose for cross-reference:
- reference to other study
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-05-31 to 2019-07-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 30 May 2008
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- ca. 98.6 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 600 g/L
- Temp.:
- 20 °C
- pH:
- 3.7 - 4
- Conclusions:
- The water solubility of the test item has been determined to be 98.6 g /L of solution at 20.0 ± 0.5 ºC.
- Executive summary:
The water solubility of the test item has been determined to be 98.6 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No. 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Visual
The water solubility in the visual preliminary test was observed to be in the range of 32.7 to 49.0 g/L.
Table 1: copper concentrations (mg/L) and the calculated test item concentrations (g/L)
Sample number |
Time shaken at ~ 30 ºC (hours) |
Copper concentration (mg/L) |
Mean copper concentration (mg/L) |
Mean test item concentration (g/L) |
Solution pH |
1A | 72 | 3.259 x 10^4 | 3.258 x 10^4 | 97.2 | 3.7 |
1B | 72 | 3.256 x 10^4 | |||
2A | 48 | 3.407 x 10^4 | 3.405 x 10^4 | 102 | 4.0 |
2B | 48 | 3.402 x 10^4 | |||
3A | 24 | 3.254 x 10^4 | 3.250 x 10^4 | 97.0 | 3.8 |
3B | 24 | 3.246 x 10^4 |
On completion of the equilibration period, the samples were clear, blue solutions with excess test item present at the bottom of the test vessels. The solutions were decanted, avoiding excess test item prior to centrifugation. After centrifugation, the supernatant was taken for analysis. The supernatant was visually observed to be clear/blue and free from undissolved test item.
As the water solubility was determined during the preliminary test to be above 10-2 g/L, the flask shaking test was performed.
All individual water solubility results were within ± 15% of the mean, thus satisfying the criteria specified in the guidelines.
Data source
Reference
- Reference Type:
- other: Calculation
- Title:
- Calculation of partition coefficient based solubility in water and octanol
- Author:
- ERM
- Year:
- 2 020
- Bibliographic source:
- not applicable
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- Annex 1
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Copper diformate
- EC Number:
- 208-865-8
- EC Name:
- Copper diformate
- Cas Number:
- 544-19-4
- Molecular formula:
- CH2O2.1/2Cu
- IUPAC Name:
- copper diformate
- Test material form:
- solid: particulate/powder
- Details on test material:
- blue in colour
Constituent 1
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- > -4.8
- Temp.:
- 20 °C
- pH:
- 7
- Details on results:
- The estimation method according to EU A.8 (annex 1) using the octanol and water solubility for Copper diformate was applied. The test item has a water solubility of 98.6 g/L and a octanol solubility of < 0.0014 g/ at 20 °C. The estimation results in a log Pow > -4.8 for Copper diformate.
Applicant's summary and conclusion
- Conclusions:
- A partition coefficient for Copper Diformate was determined based on estimation method P ow = saturation c(n-octanol)/ c(water).
The Partition coefficient for Copper Diformate Log Kow was estimated to be >-4.8 at 20°C according to estimation method (EU A.8, Annex 1) - Executive summary:
It is technically not feasible to measure an octanol-water partition coefficient for Copper Diformate by OECD 107. It may be possible to obtain a ratio of saturated water solubility (OECD 105) and saturated octanol solubility (CIPAC method MT 181). As the test item was undissolved in the highest dilution of the study , no exact n-Octanol solubility was determined and only a range could be specified. Therefore employing estimation method (EU A.8 , Annex 1) partition coefficient of >-4.8 Log Kow at 20°C was calculated.
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