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EC number: 805-440-4 | CAS number: 22972-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Preliminary Test (Pre-test): 2019-08-12 to 2019-08-15
Main test: 2019-08-26 to 2019-08-29 - Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Version / remarks:
- 2011
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (1S,4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-2-en-1-ol
- Cas Number:
- 22972-51-6
- Molecular formula:
- C10H16O
- IUPAC Name:
- (1S,4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-2-en-1-ol
- Test material form:
- liquid
- Details on test material:
- Test item: (1S,4R)-1-Methyl-4-(prop-1-en-2-yl)cyclohex-2-enol
CAS number: 22972-51-6
Physical state: Liquid
Storage: Room temperature
Constituent 1
- Specific details on test material used for the study:
- Test item: (1S,4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-2-en-1-ol
CAS number: 22972-51-6
Physical state: Liquid
Storage: room temperature
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- study. Algal biomass in each flask was measured by under microscope at 0, 24 ± 2, 48 ± 2, 72 ± 2 hours aft er treatment, measured the pH
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test article “Menthadienol (PMDOL)” solution were prepared and 10 mL of the test article so solutions were added to reaction mixture contains 80 mL growth medium, 10 mL algae (1 x 10^5 cells/mL) solution in each treatment group, and the growth medium is used as control in this study.
According to the results of the preliminary test, the highest concentration of main test was determined as 100 mg/L and was further taken 2-fold serial dilution of test article solutions and mad e to 50 mg/L, 25 mg/L, 12.5 mg/L and 6.25 mg/L to apply in other treatment groups.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Test species: Pseudokirchneriella subcapitata
Source: Freshwater Bioresource Center of National Chiayi University Controls
The algae were cultured 7 days in advance until the test starts.
Initial cells density: 10,000 cells/mL
Study design
- Test type:
- static
- Water media type:
- other: Growth medium
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 23 ± 2°C, in study period, the algae is cultured in the algae incubator.
- pH:
- t=0h: 7.5-7.6
t=72h: 7.4-7.6 - Nominal and measured concentrations:
- Main test:
Nominal test concentrations: 100mg/L, 50 mg/L, 25 mg/L, 12.5 mg/L and 6.25 mg/L
Measured test concentration:
at day 0: 90.79 mg/L, 47.12 mg/L, 23.17 mg/L, 10.82 mg/L, 5.99 mg/L
at day 3: 80.05 mg/L, 42.65 mg/L, 21.99 mg/L, 10.24 mg/L, 5.59 mg/L - Details on test conditions:
- TEST SYSTEM
- vessel: 250 mL glass flasks and test article solution is 100 mL/vessel
-Temperature: 23 ± 2°C, in study period, the algae is cultured in the algae incubator.
-Light intensity: 4440~8880 lux; continuous illumination.
-Type of test: Incubation with rotary shaking approximately 100 rpm.
-Duration: 72 ± 2 hours.
GROWTH MEDIUM: Preparation according to the OECD 201 Guideline
Measurements:
-pH was measured at the beginning and at the end of the test. Temperature was continuously measured in a control vessel.
-Analysis of all test concentrations at the beginning and at the end of the test were recommended to measure and should be remained within 80-120 % of nominal concentration.
-At the end of the final test microscopic observations were performed on all test concentrations to observe for any abnormal appearance of the algae. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 57.03 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC20
- Effect conc.:
- 2.47 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.48 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 6.25 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Remarks on result:
- not determinable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- PMDOL is hazardous to the aquatic environment and classified into GHS Acute aquatic hazard Category 3 – 72 h EC50 (for algae or other aquatic plants) > 1 0mg/L but ≤ 100 mg/L.
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