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EC number: 844-232-8 | CAS number: 102731-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No data on the test item is available. With the read-across substances the following results were obtained:
Acute oral, rat (CAS 504-63-2): Discriminating dose > 9450 mg/kg bw
Acute oral, rat (CAS 124-07-2): LD50 > 10000 mg/kg
Acute intraperitoneal, rat (CAS 504-63-2): LD50 > 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to Chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- not specified
- Dose descriptor:
- discriminating dose
- Effect level:
- 9 450 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Source Substance 1 (CAS 504-63-2)
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to Chapter 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Source Substance 2 (CAS 124-07-2)
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- according to guideline
- Guideline:
- other: Regulation for the Enforcement of the Federal Hazardous Substances Act
- Version / remarks:
- Revised, Federal Register, September 17, 1964
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: Title 49, Department of Transportation Code of Federal Regulation, Section 173, 240
- Version / remarks:
- Federal Register, February 12, 1973
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality up to 10000 mg/kg bw.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 was observed to be > 10000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study according to Regulation for the Enforcement of the Federal Hazardous Substances Act (Revised, Federal Register, September 17, 1964) and Title 49, Department of Transportation Code of Federal Regulation, Section 173, 240 (Federal Register, February 12, 1973) albino rats were given the test item over a period of 14 days. The animals demonstrated a weight gain of at least 30% over original body weight during the fourteen day test period and were within normal limits for rats of the age, sex and strain used in this study. The LD50 was observed to be > 10000 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1941-02-20
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- The test item was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1.05 to 19.95 g/kg bw.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1050, 2100, 3150, 4200, 5250, 6300, 7350, 8400, 9450, 10500, 11550, 12600, 13650, 14700, 15750, 16800, 17850, 18900, 19950 mg/kg bw
- No. of animals per sex per dose:
- At least 5 rats were used for each dose.
- Control animals:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- discriminating dose
- Effect level:
- 9 450 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The mortality was found to be 100 % for doses of 18.9 and 19.95 g/kg bw. The mortality varied from 10 to 64 % for doses from 11.55 to 17.85 g/kg bw. No rats died for doses from 1.05 to 9.45 g/kg bw.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral non lethal dose was found to be 9.45 g/kg bw.
- Executive summary:
In an acute oral toxicity study the test item was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1050 to 19950 mg/kg bw. The mortality was found to be 100 % for doses of 18900 and 19950 mg/kg bw. The mortality varied from 10 to 64 % for doses from 11550 to 17850 mg/kg bw. No rats died for doses from 1050 to 9450 mg/kg bw.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 10 000 mg/kg bw
- Quality of whole database:
- Peer reviewed publications
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data on the test item is available. Read-across was done to the two potential degradation products of the registered substance.
In an acute oral toxicity study source substance 1 (CAS 504-63-2) was administered gastrically with the aid of a suitable metal tube to 132 rats, in doses from 1050 to 19950 mg/kg bw. The mortality was found to be 100 % for doses of 18900 and 19950 mg/kg bw. The mortality varied from 10 to 64 % for doses from 11550 to 17850 mg/kg bw. No rats died for doses from 1050 to 9450 mg/kg bw.
In an acute oral toxicity study with source substance 2 (CAS 124-07-2) according to Regulation for the Enforcement of the Federal Hazardous Substances Act (Revised, Federal Register, September 17, 1964) and Title 49, Department of Transportation Code of Federal Regulation, Section 173, 240 (Federal Register, February 12, 1973) albino rats were given the source substance (124-07-2) over a period of 14 days. The animals demonstrated a weight gain of at least 30% over original body weight during the fourteen day test period and were within normal limits for rats of the age, sex and strain used in this study. The LD50 was observed to be > 10000 mg/kg bw.
Source substance 1 (CAS 504-63-2) was injected intraperitoneal with increasing dose levels to a group of six mice. The injection volume was 0.01 mL/g bw. The 24 h LD50 was found to be 68.8 mmol/kg bw and the 144 hr LD50 was found to be 62.8 mmol/kg bw. These values coreespond to 5236 mg/kg bw and 4779 mg/kg bw, respectively.
Based on the results both source substances are absolutely non toxic when administrated via the oral routes showing toxicity on in very high doses well above the limit dose of 2000 mg/kg bw. In conclusion this weight of evidence approach shows that also the registered substance is assumed to be absolutely non acute toxic (oral).
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. Based on available data on acute toxicity, the test item is classified and labelled as not acute oral toxic according to Regulation (EC) No 1272/2008 (CLP), as amended for the fifteenth time in Regulation (EU) No 2020/1182.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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