Registration Dossier
Registration Dossier
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EC number: 943-705-7 | CAS number: 947686-05-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
- Cas Number:
- 947686-05-7
- Molecular formula:
- C18H18O2
- IUPAC Name:
- 3',5-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,4'-diol; 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- confirm to the best of knowldge#
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 - <= 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Executive summary:
The LD50 of the test item “Magnolia Officinalis Bark Extract” is greater than 2000 mg/kg and lower than 5000 mg/kg body weight after single oral administration to Wistar rats.
Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423 (USA) it can be concluded that the test item “Magnolia Officinalis Bark Extract” is according to GHS criteria classified in Category 5 with a LD50 cut off value equal to 2500 mg/kg body weight, after single oral administration to Wistar rats. It can be stated that Magnolia Officinalis Bark Extract shows low acute toxicity regarding oral toxicity test.
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