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Diss Factsheets
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EC number: 701-328-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study for Epoxide 8 which has different exposure route concern comparing with the target material. Exposure concentrations were not measured. Limited documentation. Thus the study is used for read-across to avoid duplicate tests.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- The test material was sprayed undiluted for fifteen seconds into an inhalation chamber containing four rabbits and ten rats. The chamber was sealed and flushed with air under reduced pressure for one hour. This procedure was repeated three times daily for
two days for the test material.
Necropsies were performed on each group of animals the morning following the last treatment. Blood and tissues were taken for examination. - GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- Epoxide 8
- IUPAC Name:
- Epoxide 8
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- CD-1
- Details on test animals or test system and environmental conditions:
- Ten (10) Charles River CD Rats and four (4) New Zealand Albino Rabbits.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The test material was sprayed undiluted for fifteen seconds into an inhalation chamber containing four rabbits and ten rats. The chamber was sealed and flushed with air under reduced pressure for one hour. This procedure was repeated three times daily for two days for the test material.
- Analytical verification of test atmosphere concentrations:
- no
- No. of animals per sex per dose:
- 10 rats and 4 rabbits
Results and discussion
Effect levels
- Remarks on result:
- other: No changes were found which related to the test treatment
- Mortality:
- No deaths
- Clinical signs:
- other: No symptoms noted
- Body weight:
- Average body weights were normal
- Gross pathology:
- No lesions were noted grossly in either species exposed to Epoxide No.8.
- Other findings:
- Microscopic examination of tissues showed no unusual changes except myocarditis in all four rabbits. The myocarditis was considered unrelated to test treatment since the population of rabbits being used had a higher than normal incidence of myocarditis.
Average blood values and organ/body weight-ratios were normal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Epoxide No. 8 does not pose any apparent inhalation problem since it has a low toxicity and vapour pressure.
- Executive summary:
The test material was sprayed undiluted for fiftheen seconds into an inhalation chamber containing four rabbits and ten rats. The chamber was sealed and flushed with air under reduced pressure for one hour. This procedure was repeated three times daily for two days for the test. material. Necropsies were performed on each group of animals the morning following the last treatment. Blood and tissues were taken for examination.
No lesions were noted grossly in either species exposed to Epoxide No.8. Microscopic examination of tissues showed no unusual changes except myocarditis in all four rabbits. The myocarditis was considered unrelated to test treatment since the population of rabbits being used had a higher than normal incidence of myocarditis. Average blood values and organ/body weight-ratios were normal.
Epoxide No. 8 does not pose any apparent inhalation problem since it has a low toxicity and vapour pressure.
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