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Diss Factsheets
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EC number: 948-916-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Jul. 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- Jan. 2014
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: slow stir method
Test material
- Reference substance name:
- vegetable oil mono- and polyunsaturated C16-C22 triglycerides
- Molecular formula:
- C51H92O6 to C69H128O6
- IUPAC Name:
- vegetable oil mono- and polyunsaturated C16-C22 triglycerides
- Reference substance name:
- dimers of vegetable oil mono- and polyunsaturated C16-C22 triglycerides
- Molecular formula:
- C102H186O12 to C138H256O12
- IUPAC Name:
- dimers of vegetable oil mono- and polyunsaturated C16-C22 triglycerides
- Reference substance name:
- trimers of vegetable oil mono- and polyunsaturated C16-C22 triglycerides
- Molecular formula:
- C153H280O18 to C207H388O18
- IUPAC Name:
- trimers of vegetable oil mono- and polyunsaturated C16-C22 triglycerides
- Reference substance name:
- tetramers and higher oligomers of vegetable oil mono- and polyunsaturated C16-C22
- Molecular formula:
- C204H374O24 and higher oligomers
- IUPAC Name:
- tetramers and higher oligomers of vegetable oil mono- and polyunsaturated C16-C22
- Test material form:
- liquid: viscous
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- 0.33 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 0.5 g/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 5.85 - 6.16
- Water solubility:
- 0.44 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 5.85 - 6.16
Any other information on results incl. tables
Measurements during equilibration
Day |
Temperature |
pH* |
Measured |
Concentration |
Conc. Test |
Difference |
1 |
20.0 |
5-6 |
386 390 369 |
0.27 |
0.35 |
|
2 |
20.0 |
5-6 |
384 351 349 |
0.25 |
0.33 |
-6.6 |
3 |
20.5 |
5-6 |
351 377 365 |
0.26 |
0.33 |
1.0 |
3 (blank) |
20.0 |
6 |
9 0 12 |
< LOQ |
< LOQ |
|
* measured using pH paper
Measurements at plateau
Flask |
Temp. [°C] |
pH* |
Measured Areas |
Concentration DOC Mean [mg/L] |
Conc. test item |
2 |
20.5 |
6.16 |
388 376 357 |
0.26 |
0.34 |
3** |
20.5 |
6.05 |
0 0 0 |
< LOQ |
< LOQ |
4** |
20.5 |
5.96 |
0 26 5 |
< LOQ |
< LOQ |
5 |
20.5 |
6.06 |
478 426 419 |
0.32 |
0.42 |
6 |
20.5 |
5.85 |
457 454 464 |
0.34 |
0.44 |
** a sample preparation error was suspected, therefore the measurement was repeated (see next table).
Measurements at plateau
Flask |
Temp. [°C] |
pH* |
Measured Areas |
Concentration DOC Mean [mg/L] |
Conc. test item |
3 |
20.0 |
- |
369 353 372 |
0.23 |
0.33 |
4 |
20.0 |
- |
19 17 4 |
< LOQ |
< LOQ |
The repeated measurement of flask 3 confirmed the presumption of a sample preparation error. The repeated measurement of flask 4 confirms the first measurement. Flask 4 was stated as an outlier and was not use in the evaluation.
Conclusion
As solubility was dependent on the nominal concentration, the solubility of the test item in water can be stated as 0.33 mg/L - 0.44 mg/L for the nominal concentration range 0.5 – 10 g/L.
Applicant's summary and conclusion
- Conclusions:
- The water solubility was found to be dependent on the nominal concentration. Therefore, the solubility of the test item in water can be stated as 0.33 mg/L - 0.44 mg/L for the nominal concentration range 0.5 – 10 g/L.
- Executive summary:
The solubility of the test item “Oligomerisation product obtained by plasma treatment of vegetable oil mono- and polyunsaturated C16-C22 triglycerides” in water was determined by measurement of dissolved organic carbon (DOC) concentrations in the filtrated test solutions using a total organic carbon (TOC) analyser.
From solubility pre-tests performed under non-GLP conditions in the ecotoxicological department, the water solubility was estimated to be below 100 mg/L. Therefore, the preliminary test mentioned in the guideline was not performed and a minimum nominal loading rate of 500 mg/L test item was used. As dependency of the water solubility on the amount of the test item added was expected, different loading rates were used in the main test. Because the test item is a liquid with a density lower than water, the slow stirring method was used to prevent the formation of emulsions. Sampling at the bottom of the flasks was performed to avoid carryover of the test item from the surface.
In the main test, six different test item loading rates were chosen to study the effect of the loading rate on the measured water solubility: 500, 1000, 2500, 5000, 7500 and 10000 mg/L. Three flasks (1A – 1C) with the same loading rate (5000 mg/L) were used during the equilibration phase. Seven vessels (flasks blank, 1C (for the sampling point 72 h) and 2 – 6) were put onto the Magnetic stirrer immediately and slow stirring (100 rpm) was started.
After 24 ± 2 h, flask 1B (for the sampling point 48 h) and after 48 ± 2 h, flask 1A (for the sampling point 24 h) were put on the stirrer and all flasks were stirs for further 24 ± 2 h at room temperature. Then, flasks 1A – 1C were removed from the stirrer, tempered at 20.0 ± 0.5 °C, samples were taken, membrane filtered and analysed for DOC via TOC analyser.
No upward tendency in the last three values, the test was finished on day 2. The final measurement was performed as determination from flasks 2 – 6. DOC was measured via TOC analyser in the saturated aqueous solutions. The pH value in the flasks 2 – 6 lay in the range of 5.85 – 6.16.
A slight dependency of the solubility on the amount of the test item (nominal load) was perceived in the flasks 2 – 6.
Based on the measured values, the concentration of the test item in water was stated as
0.33 mg/L – 0.44 mg/L at 20.0 ± 0.5 °C
0.33 mg/L – 0.44 10-3 kg/m3 (SI units)
for the nominal concentration range 0.5 – 10 g/L.
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