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Diss Factsheets
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EC number: 701-310-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
An Ames test with 2,2’oxydiethanol, ethoxylated and propoxylated (>1<4.5 EO and >1<4.5 PO) was performed according to OECD TG 471 in the tester strains S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2 with and without metabolic activation. No relevant increase in the number of his+ or trp+ revertants was observed in any experiment, thus, under the experimental conditions chosen here, it is concluded that 2,2`-Oxybisethanol ethoxylated and propoxylated is not a mutagenic test substance.
Evaluation of clastogenicity in mammalian cells can reliably be performed by read-across to the structural analogues
2, 2', 2''-nitrilotriethanol, propoxylated, glycerol, propoxylated and D-glucitol, propoxylated. All 3 test substances have been tested negative for chromosomal aberrations in human lymphocytes under the conditions tested, each in absence and presence of a metabolic activating system.
The results from a mammalian point mutation assay have been 'read across' from 2, 2', 2''-nitrilotriethanol, propoxylated. 2,2',2''-Nitrilotriethanol, propoxylated did not induce mutagenic effects in the in vitro gene mutation assay (HPRT test) with Chinese hamster V79 cells in the presence and absence of a metabolic activation system.
Short description of key information:
Five in vitro mutagenicity tests using different end points were all negative. Therefore further testing is not required.
The Ames assay on mutagenicity in bacterial cells was performed with 2,2’-oxydiethanol, ethoxylated and propoxylated, >1<4.5 EO and >1<4.5 PO), whereas all other end point (mutagenicity and genetic toxicity in mammalian cells) were reliably read-acrossed from near structural analogues (molecules with similar core molecules and/or side chains), as permitted by Annex XI para 1.5.
One nominally from 2, 2', 2''-nitrilotriethanol, propoxylated, one from glycerol, propoxylated, and one from D-glucitol, propoxylated see report from Paul Illing Consultancy Services Ltd and Marlin Consultancy Illing and Barratt, 2007 and 2010. The report identifies that these substances are the most bioavailable of the polyols. Thus, it is inappropriate to undertake the tests on diethyleneglycol, propoxylated. For further details concerning the groupings consult Illing and Barratt (2007 and 2010).
All assays in vitro assays presented indicated negative results, furthermore the molecule does not contain a structural allert for genotoxicity.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Findings from in-vitro genotoxicity testing do not warrant classification and labelling according to GHS (EU).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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