Registration Dossier
Registration Dossier
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EC number: 701-333-0 | CAS number: -
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Remarks:
- READ-across with Oxirane, (butoxymethyl)- (n-Butyl glycidyl ether) CAS: 2426-08-6
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- It is in the QSAR summary report: READ-across with Oxirane, (butoxymethyl)- (n-Butyl glycidyl ether) CAS: 2426-08-6
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- It is in a screening assessment prepared by Canadian authority.
- GLP compliance:
- not specified
- Remarks:
- It is not mentioned if the test was done in a GLP laboratory or not.
Test material
- Reference substance name:
- Butyl 2,3-epoxypropyl ether
- EC Number:
- 219-376-4
- EC Name:
- Butyl 2,3-epoxypropyl ether
- Cas Number:
- 2426-08-6
- Molecular formula:
- C7H14O2
- IUPAC Name:
- 2-(butoxymethyl)oxirane
- Test material form:
- not specified
1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LOEL
- Effect level:
- ca. 100 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- gross pathology
Target system / organ toxicity
- Key result
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 100 mg/kg bw/day
- System:
- other: liver
- Organ:
- liver
- Treatment related:
- yes
- Dose response relationship:
- yes
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- LOEL: 100 mg/kg-bw
- Executive summary:
LOEL: 100 mg/kg-bw
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