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EC number: 425-450-9 | CAS number: 294-90-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for test
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 425-450-9
- EC Name:
- -
- Cas Number:
- 294-90-6
- Molecular formula:
- C8H20N4
- IUPAC Name:
- 1,4,7,10-tetraazacyclododecane
- Test material form:
- not specified
- Details on test material:
- - Substance name: 1,4,7,10-tetraazacyclododecane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Crl: (WI) BR
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: NaCl/Polyoxyl-50-stearate (Myrj53)
- No. of animals per sex per dose:
- Preliminary sighting study: 3 (male)Preliminary sighting study: 3 (female)Main study: 3 (male)Main study: 3 (female)
- Details on study design:
- Preliminary sighting study:At 2000 mg/kg 6 of 6 animals died.Main study:200 mg/kg: no abnormal findings occurred
Results and discussion
- Preliminary study:
- Species/strain: rat, Wistar2000 mg/kg bw: Evident toxicity: Y; Mortality: Y500 mg/kg bw: not administered50 mg/kg bw: not administered5 mg/kg bw: not administered<5 mg/kg bw: not administered200 mg/kg bw: Evident toxicity: N; Mortality: NObservations:2000 mg/kg: reddish rhinorrhea and silorrhea in one maleafter 30 min of treatment, additionally slight apathy,incomplete eylid closure, ruffled fur, and abnormalbreathing from ca. 6h after treatment in all males, femaleswithout clinical findings.
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 200 mg/kg bw
- Effect level:
- 200 mg/kg bw
- Remarks on result:
- other: No. with evident toxicity: 0; No. of deaths: 3; No of animals used:3
- Effect level:
- 200 mg/kg bw
- Remarks on result:
- other: No. with evident toxicity: 3; No. of deaths: 3; No. of animals used: 3
- Effect level:
- 2 000 mg/kg bw
- Remarks on result:
- other: No. with evident toxicity: 0; No. of deaths: 0; No. of animals used: 3
- Clinical signs:
- other: 2000 mg/kg: males: reddish rhinorrhea and silorrhea in one animal after 30 min of treatment, additionally slight apathy, incomplete eylid closure, ruffled fur, and abnormalbreathing from ca. 6 h after treatment in all animals, all animals dead after 24 h
- Gross pathology:
- 2000 mg/kg (males and females): necropsy revealed multifocal reddening in stomach, paleness of spleen, discoloration in lung lobes200 mg/kg (males and females): no abnormal findings
Applicant's summary and conclusion
- Interpretation of results:
- other: Harmful
- Remarks:
- Migrated information criteria interpretation of results: EU
- Conclusions:
- Test substance in Wistar rats has a discriminating dose of >=200 mg/kg bw.
- Executive summary:
The acute toxicity of test substance was performed according to the OECD 423 (1996) Guideline under GLP conditions.
For this limit test type, an initial concentration of 200 mg/kg bw of tst substance in vehicle ( NaCl/Polyoxyl-50 -stearate (Myrj53)) were administered orally to 3 male and 3 female Wistar rats. Due to the 100% mortality of the initial dose, for the main test a concentration of 200 mg/kg bw concentration was used. The effects of test substance on animals were evaluated using the clinical signs, gross pathology, body weight and necropsy.
Test substance in Wistar rats has a discriminating dose of >=200 mg/kg bw.
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