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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2018 - Dec 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- > 2 222.8 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- ca. 5 min
- Temp.:
- 22 °C
- Remarks on result:
- other: pH not determined
- Details on results:
- The first preliminary test at room temperature showed, that the water solubility of the test item was above 1001.9 g/L. The observations of the preliminary test are summarized in Table 1.
With a solubility of the test item in water at room temperature of > 10 mg/L, the flask method has to be performed.
Due to the high water solubility of the test item further tests in a simplified flask method were performed. The results of these tests are shown in Table 2.
From these preliminary tests, the water solubility of the test item can be estimated to be >2222.8 g/L. - Conclusions:
- The water solubility at 22 °C of the test item could be estimated from a simplified flask method to be > 2222.8 g/L.
- Executive summary:
According to OECD Test Guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6 the water solubility at 22 °C of the test item could be estimated from a simplified flask method to be > 2222.8 g/L. The study was conducted in accordance with GLP.
Reference
Table 1: Preliminary test for the water solubility
| Amount of test item [mg] | Added volume of water [mL] | Ultrasonic bath [min] | Remark |
| 500.96 | 0.5 | 5 | dissolved |
Table 2: Preliminary test for the possibility of stirring
| Total amount of added test item [g] | Volume of water [mL] | Remark | |
| 45.7 | 25 |
|
|
| 51.1 | 25 | dissolved, stirring possible | |
| 52.9 | 25 | dissolved, stirring possible | |
| 54.6 | 25 | dissolved, stirring possible | |
| 55.6 | 25 | dissolved, very viscous (jellylike), stirring not possible anymore |
Description of key information
According to OECD Test Guideline 105 (1995) and Regulation EC No. 440/2008 Method A.6 the water solubility at 22 °C of the test item could be estimated from a simplified flask method to be > 2222.8 g/L. The study was conducted in accordance with GLP.
Key value for chemical safety assessment
- Water solubility:
- 2 222.8 g/L
- at the temperature of:
- 22 °C
Additional information
The water solubility is higher than the stated value for CSA. At this value stirring of the solution was not possible anymore.
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