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EC number: 278-601-4 | CAS number: 77061-58-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12Dec1978 to 24Jan1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Study was conducted in 1978-1979, no test guideline was available.
- GLP compliance:
- not specified
- Remarks:
- Study was conducted in 1978-1979, facility was not noted to be GLP compliant. (although a study director was appointed and arhiving of test data was undertaken)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- EC Number:
- 278-601-4
- EC Name:
- 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- Cas Number:
- 77061-58-6
- Molecular formula:
- C13H18N5.Cl
- IUPAC Name:
- 2-[[4-(dimethylamino)phenyl]azo]-1,3-dimethyl-1H-imidazolium chloride
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Test Material Name: FAT 31063/B
Test material received: November 10, 1978
Batch No.: EN 13465.76
Physical appearance: solid
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF) strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Healthy random bred rats of the Tif: RAIf (SPF) strain (7 to 8 weeks old) raised on the premises were used for these experiments. They were kept at a room temperature of 22 + 1° C, at a relative humidity of 55 + 5 % and on a 10 hours light cycle day. They received ad libitum rat food - NAFAG, Gossau SG - and water. Prior to treatment the animals were adapted to our laboratories for a minimum of 4 days.
Administration / exposure
- Route of administration:
- other: oral intubation
- Vehicle:
- polyethylene glycol
- Remarks:
- polyethylene glycol (PEG 400)
- Details on oral exposure:
- FAT 31063/B was suspended. Before treatment the suspension was homogeneously dispersed with an Ultra-Turrax and during treatment it was kept stable with a magnetic stirrer.
Animals fasted overnight were treated by oral intubation. Physical condition and rate of deaths were monitored throughout the whole observation period. - No. of animals per sex per dose:
- 5 animals per sex per dose.
- Control animals:
- no
- Statistics:
- LD 50 including 95 % confidence limits were calculated by the logit model.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 020 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 696 - <= 1 529
- Mortality:
- See table 1 for death rate per group.
- Clinical signs:
- See tables 3,4,5,6 & 7 for clinial signs
- Body weight:
- See table 1 for bodyweight changes
- Gross pathology:
- Autopsies:
Dead and killed Animals: No substance related gross organ changes were seen.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 of Basic Red 51 in rats of both sexes observed over a period of 14 days is 1020 (696-1529) mg/kg. Based on EC 1272/2008 and utilising the oral LD50 of 1020 mgkg, Basic Red 51 should be classified as Acute Oral Toxicitiy Category 4 (H302).
- Executive summary:
The acute oral LD50 of Basic Red 51 in rats of both sexes observed over a period of 14 days is 1020 (696-1529) mg/kg. Based on EC 1272/2008 and utilising the oral LD50 of 1020 mgkg, Basic Red 51 should be classified as Acute Oral Toxicitiy Category 4 (H302).
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