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EC number: 949-957-4
CAS number: -
The IVIS obtained after treatment with the test material was 5.8 and,
thus higher than 3 and lower than 55, i.e. according to OECD 437 no
prediction can be made regarding the eye hazard potential of the test
The results are given in the following table:
per group (mean value)
0.9% sodium chloride solution
Test material preparation
No observations (e.g. tissue peeling, residual test chemical,
non-uniform opacity patterns) were seen in a visually inspection of the
corneas after treatment.
After treatment with the negative control (0.9% sodium chloride
solution) the calculated IVIS was 0.1 and, thus, within three standard
deviations of the current historical mean of the negative control (IVIS:
-1.4 – 3.1). After treatment with the positive control (20% Imidazole)
the calculated IVIS was 117.0 and, thus, also within two standard
deviations of the current historical mean of the positive control (IVIS:
82.3 – 132.4). Therefore, the study fulfilled the acceptance criteria.
The resulting classification of the test item in this study is
unequivocal and no borderline results were obtained. Therefore, a single
testing run composed of three corneas per group was considered
This study was performed according
to GLP and the methods applied are fully compliant with OECD TG 437.
the conditions of the present study, the eye hazard potential of the
test item cannot be predicted.
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