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Diss Factsheets
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EC number: 473-370-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 February 2007 to 18 April 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 9439, 1999
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Municipal sewage treatment plant of Waterschap De Maaskant, 's-Hertogenbosch
- Storage conditions: under aeration
- Storage length: not indicated
- Preparation of inoculum for exposure: settled during 30-65 min and decanted to 10 mL/L of mineral medium
- Pretreatment: none
- Concentration of sludge: ss 4.4 g/L (first test), ss 3.7 g/L (second test)
- Water: purified by reverse osmosis and passed over activated carbon and ion exchange cartridges - Duration of test (contact time):
- 29 d
- Initial conc.:
- ca. 16 mg/L
- Based on:
- test mat.
- Initial conc.:
- ca. 44 mg/L
- Based on:
- ThCO2
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Remarks:
- captured by 2 Ba(OH)2 traps
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to OECD 301B
- Solubilising agent: none (direct weighing into 2 L of the medium with microbial organisms and mineral components
- Test temperature: 22.0-23.9 ˚C
- pH: 7.4-7.9
- pH adjusted: no
- Aeration of dilution water: synthetic air (30-100 mL/min)
- Suspended solids concentration: SS test 1 4.4 g/L; test 2 3.7 g/L
- Continuous darkness: yes (darkbrown bottles)
TEST SYSTEM
- Culturing apparatus: 2L darkbrown glass vessel with 3 CO2 absorbers (eaach containing 100 mL 0.0125 M Ba(OH)2) in series
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: bubbling of synthetic aire
SAMPLING
- Sampling frequency: every 2-3 days from the first Ba(OH)2 trap during the first 10 days, every fifth day thereafter
- Sample storage before analysis: no data
- Other: on day 0 and 28 pH was measured with phenolphthalein;
On day 28 1 mL HCl (37%) was added to the bottles and after aeration overnight the final titration was done on day 29
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 bottles
- Toxicity control: 1 bottle
- Substance: 2 bottles
- Positive control (sodium acetate) 1 bottle
STATISTICAL METHODS: - Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 2 - <= 3
- Sampling time:
- 9 d
- Remarks on result:
- other: values for test 1 and 2
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 2 - <= 5
- Sampling time:
- 14 d
- Remarks on result:
- other: values for test 1 and 2
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 18 - <= 33
- Sampling time:
- 19 d
- Remarks on result:
- other: values for test 1 and 2
- Remarks:
- deviation between the two bottles was > 20% in test 1
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 46 - <= 59
- Sampling time:
- 23 d
- Remarks on result:
- other: values for test 1 and 2
- Parameter:
- % degradation (CO2 evolution)
- Value:
- >= 67 - <= 79
- Sampling time:
- 29 d
- Remarks on result:
- other: values for test 1 and 2
- Remarks:
- deviation between the two bottles was > 20% in both tests
- Details on results:
- see attached tables
Toxicity controls showed 15% degradation in test 1 and 7% degradation in test 2 on day 14 - Results with reference substance:
- 74% biodegradation on day 14 in both tests
- Validity criteria fulfilled:
- no
- Remarks:
- partly see above
- Interpretation of results:
- inherently biodegradable
- Remarks:
- the study director concluded that the deviation from the validity criteria has not affected the conclusion of the study
- Conclusions:
- The substance is considered to be almost readily biodegradable
- Executive summary:
In a CO2 evolution test, the substance showed very limited biodegradation until day 14 to 19. Thereafter in test 1 the substance met the 10-window criterion in one of the bottles, but not in the replicate (biodegradation 80 and 56% on day 29). In the second test the substance met the 10-day window in both replicates (biodegrdation 67 and 95% on day 29). The difference between the replicates was > 20% during part of the tests. The toxicity control showed that the substance inhibits bacterial growth.
The results are indicative for ready biodegradability of the substance, although the criteria are not completely met.
Reference
Description of key information
In a CO2 evolution test, the substance showed very limited biodegradation until day 14 to 19. Thereafter in test 1 the substance met the 10-window criterion in one of the bottles, but not in the replicate (biodegradation 80 and 56% on day 29). In the second test the substance met the 10-day window in both replicates (biodegrdation 67 and 95% on day 29). The difference between the replicates was > 20% during part of the tests. The toxicity control showed that the substance inhibits bacterial growth.
The results are indicative for ready biodegradability of the substance, although the criteria are not completely met.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.