Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The following modeling approaches and methods will be used in the analysis:
• OASIS TIMES (AMES, CA, ER, AR) and Catalogic (301C) modeling approach
• Toolbox 4.2 (TB) for searching of analogues and read-across analysis
• Available documented data and expert evaluation

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Principles of method if other than guideline:
The following modeling approaches and methods will be used in the analysis:
• OASIS TIMES (AMES, CA, ER, AR) and Catalogic (301C) modeling approach
• Toolbox 4.2 (TB) for searching of analogues and read-across analysis
• Available documented data and expert evaluation

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction mass of 1-hydroxypropan-2-yl diethylphosphinate and 2-hydroxypropyl diethylphosphinate
Cas Number:
2230512-72-6
Molecular formula:
C7H17O3P
IUPAC Name:
Reaction mass of 1-hydroxypropan-2-yl diethylphosphinate and 2-hydroxypropyl diethylphosphinate
Test material form:
liquid
Details on test material:
R&D level

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Key result
Dose descriptor:
other: QSAR evaluation, not quantitative
Effect level:
ca. 0 other: QSAR evaluation, not quantitative
Based on:
other: QSAR evaluation, not quantitative
Sex:
not specified
Basis for effect level:
other: QSAR evaluation, not quantitative
Remarks on result:
other:
Remarks:
QSAR evaluation, not quantitative

Target system / organ toxicity (P0)

Key result
Critical effects observed:
not specified
System:
other:

Results: P1 (second parental generation)

Effect levels (P1)

Key result
Dose descriptor:
other: QSAR evaluation, not quantitative
Effect level:
ca. 0 other: QSAR evaluation, not quantitative
Based on:
other: QSAR evaluation, not quantitative
Sex:
not specified
Basis for effect level:
other: QSAR evaluation, not quantitative
Remarks on result:
other:
Remarks:
QSAR is not quantitative

Target system / organ toxicity (P1)

Key result
Critical effects observed:
not specified

Results: F1 generation

Effect levels (F1)

Key result
Dose descriptor:
other: QSAR evaluation, not quantitative
Generation:
other: QSAR evaluation, not quantitative
Effect level:
ca. 0 other: QSAR evaluation, not quantitative
Based on:
other: QSAR evaluation, not quantitative
Sex:
not specified
Basis for effect level:
other: QSAR evaluation, not quantitative
Remarks on result:
other:
Remarks:
QSAR is not quantitative

Target system / organ toxicity (F1)

Key result
Critical effects observed:
not specified
System:
other: QSAR data
Organ:
other: QSAR DATA

Results: F2 generation

Effect levels (F2)

Key result
Dose descriptor:
other:
Remarks:
QSAR DATA
Generation:
F2
Effect level:
0 other: QSAR data
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: QSAR data
Remarks on result:
not measured/tested
Remarks:
Qsar is not quantitative

Overall reproductive toxicity

Reproductive effects observed:
no

Applicant's summary and conclusion

Conclusions:
• Estrogen and androgen receptor-mediated TIMES models predicts both constituents of E17-194T as not toxic as parents as a follow-up of the absence of cyclic part. TIMES ERBA with metabolic activation S9 model gives negative predictions for the metabolites as well.

• The TIMES receptor binding predictions are confirmed by the documented data of identified analogues.