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EC number: 203-207-6 | CAS number: 104-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11/12/2017 - 18/05/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: UpChem Co. Ltd., 170329
- Expiration date of the lot/batch: 28-03-2018
- Purity test date: 06-04-2017
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature, away from moisture
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: not soluble
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not observed - Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:
- Eluate:
- Differential loading:
- Controls:
- Chemical name of vehicle (organic solvent, emulsifier or dispersant):
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)):
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna was used as test system as it is a recommended species in the guideline.
6.1.2.1 Source
Ecotoxicology
Eurofins Advinus Limited
Bengaluru
India
6.1.2.2 Maintenance of Daphnia
Daphnia were maintained in the test medium. The test medium in which the daphnia were maintained was changed at least twice a week and they were fed with the unicellular green alga, Chlorella vulgaris. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- yes
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 value for P-phenylene diisocyanate at 48 hours was 4.46 mg/L based on nominal concentrations with fiducial limits at 95 % being 3.1463 and 6.3208 mg/L.
- Executive summary:
The acute immobilization effect of the test item P-phenylene diisocyanate was studied onDaphnia magna. TheDaphnia magnaof less than 24 hours old were exposed to concentrations of 0.4, 0.88, 1.94, 4.27, 9.39, 20.66, 45.46 and 100 mg/L of P-phenylene diisocyanate along with a negative and reference substance in reconstituted water at 20 ± 1oC. The number of daphniaimmobilized was recorded at 24 and 48 hours post exposure.
There was no immobilization of daphnia in the negative control and at the lowest concentration of 0.4 mg/mL either at 24 or at 48 hours post-exposure. The immobilization of daphniawas 5, 5, 35, 35, 55, 85 and 100 % at 24 hours and 15, 20, 45, 80, 85, 95 and 100 % at 48 hours post-exposure at the tested concentrations of 0.88, 1.94, 4.27, 9.39, 20.66, 45.46 and 100 mg/L ofP-phenylene diisocyanate.
There was 40 and 60% immobilization of daphnia in thereference substance (potassium dichromate), at 24 and 48-hour post exposure, respectively, indicating the sensitivity of the test procedure used.
The EC50value for P-phenylene diisocyanate at 24 hours was 11.626 mg/L based on nominal concentrations with fiducial limits at 95 % being 7.7588 and 17.4207 mg/L.
The EC50value for P-phenylene diisocyanate at 48 hours was 4.46 mg/L based on nominal concentrations with fiducial limits at 95 % being 3.1463 and 6.3208 mg/L.
Reference
Description of key information
The EC50 value for P-phenylene diisocyanate at 48 hours was 4.46 mg/L based on nominal concentrations with fiducial limits at 95 % being 3.1463 and 6.3208 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.46 mg/L
Additional information
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