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EC number: 833-435-7 | CAS number: 2133415-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: not specified
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: not specified
- Details on results:
- Oxygen consumption rates and percentage inhibition values for the control, test and reference materials are given in Table 1 (see any other information on materials and results, including tables section) . The pH values of the test preparations at the start and end of the exposure period are given in Table 2 (see any other information on materials and results, including tables section), and observations made on the test preparations throughout the study are given in Table 3 (see any other information on materials and results, including tables section)
Percentage inhibition is plotted against concentration for the reference material, 3,5 dichlorophenol only (Figure 1 attached in overall remakrs and attachments section).
The following results were derived:
ECx (3 Hours) (mg/l) 95% Confidence Limits (mg/l)
EC20 >1000 -
EC50 >1000 -
EC80 >1000 -
NOEC 1000 -
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/l.
3,5-dichlorophenol:
ECx (3 Hours) (mg/l) 95% Confidence Limits (mg/l)
EC20 2.6 -
EC50 7.9 6.1 - 10
EC80 25 -
NOEC 2.1
Variation in respiration rates of controls 1 and 2 after 3 hours contact time was ± 5%.
The validation criteria for the control respiration rates and reference material EC50 values were therefore satisfied. - Results with reference substance (positive control):
- - Results with reference substance valid?
Yes.
- Relevant effect levels:
The reference material gave a 3-Hour EC50 value of 7.9 mg/l, 95% confidence limits 6.1 - 10 mg/l.
- Other:
None. - Reported statistics and error estimates:
- None.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect of the test material on the respiration of activated sewage sludge micro-organisms gave a 3-Hour EC50 of greater than 1000 mg/l. The No Observed Effect Concentration (NOEC) after 3 hours exposure was 1000 mg/l.
- Executive summary:
Introduction. A study was perford to assess the effect of the test material 'Distillates (Fischer-Tropsch), heavy, C18-50 - branched, cyclic and linear’ on the respiration of activated sewage sludge. Thethod followed that described in the OECD Guidelines for Testing of Chemicals (1984) No 209 "Activated Sludge, Respiration Inhibition Test", Method C.11 of Commission Regulation (EC) No. 440/2008 and US EPA Draft Ecological Effects Test Guidelines OPPTS 850.6800.
Methods. Activated sewage sludge was exposed to an aqueous dispersion of the test material at concentrations of 10, 32, 100, 320 and 1000 mg/L for a period of 3 hours at a temperature of approximately 21°C with the addition of a synthetic sewage as a respiratory substrate.
The rate of respiration was determined after 3 hours contact tiand compared to data for the control and a reference material, 3,5-dichlorophenol.
Results. The effect of the test material on the respiration of activated sewage sludge gave a 3‑Hour EC50 of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was1000mg/L.
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L.
The reference material gave a 3-Hour EC50 value of 7.9 mg/L, 95% confidence limits 6.1 – 10 mg/L.
Conclusion.
The effect of the test material on the respiration of activated sewage sludge gave a 3‑Hour EC50 of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was1000 mg/L.
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L.
The reference material gave a 3-Hour EC50 value of 7.9 mg/L, 95% confidence limits 6.1 – 10 mg/L.
Reference
REFERENCES
Litchfield, J T and Wilcoxon, F (1949) A Simplified Method of Evaluating Dose-Effect Experints. J Pharmacol Exp Ther 96, 99-113.
Xlfit, ID Business Solutions Ltd.
Description of key information
The 3 -hour EC50 for GTL Base Oil
Distillates was determined to be >1000 mg/L.
The 3 -hour NOEC for GTL Base Oil Distillates was determined to be 1000
mg/L.
This data is used for read across to Alkanes, C16 -47, branched and linear.
Key value for chemical safety assessment
Additional information
The read across substance GTL Base Oil Distillates had no inhibitory effect upon activated sludge (OECD 209) in a test conducted in accordance with GLP. The 3-hr EC50 was >1000 mg/L [(3h) NOEC = 1000 mg/L].
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